53887

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1637833..1638359 Replicon chromosome
Accession NZ_CP011321
Organism Escherichia coli strain SQ88

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag SG49_RS08155 Protein ID WP_000323025.1
Coordinates 1637833..1638120 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag SG49_RS08160 Protein ID WP_000534858.1
Coordinates 1638120..1638359 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SG49_RS08115 1632857..1633072 - 216 WP_000839590.1 phage lysis protein EssD -
SG49_RS08120 1633826..1634041 - 216 WP_000066484.1 cold shock-like protein CspB -
SG49_RS08125 1634342..1634554 + 213 WP_000087756.1 cold shock-like protein CspF -
SG49_RS25465 1634609..1634698 + 90 WP_120795389.1 hypothetical protein -
SG49_RS08130 1634976..1635728 - 753 WP_001047135.1 antitermination protein -
SG49_RS08135 1635742..1636791 - 1050 WP_001393597.1 DUF968 domain-containing protein -
SG49_RS08140 1636793..1637071 - 279 WP_012304870.1 hypothetical protein -
SG49_RS08145 1637138..1637389 - 252 WP_000980994.1 hypothetical protein -
SG49_RS08150 1637606..1637761 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
SG49_RS08155 1637833..1638120 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
SG49_RS08160 1638120..1638359 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
SG49_RS23675 1638384..1638689 + 306 WP_001326990.1 hypothetical protein -
SG49_RS08165 1638892..1639224 + 333 WP_001301033.1 protein FlxA -
SG49_RS22940 1639661..1639810 - 150 WP_011443592.1 hypothetical protein -
SG49_RS08170 1639845..1640123 - 279 Protein_1572 hypothetical protein -
SG49_RS08175 1640107..1640337 - 231 WP_000920568.1 dicB transcriptional regulator DicC -
SG49_RS08180 1640421..1640828 + 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
SG49_RS08185 1640995..1641150 + 156 WP_000379575.1 DUF1391 family protein -
SG49_RS08190 1641310..1641528 + 219 WP_001171942.1 hypothetical protein -
SG49_RS08200 1642096..1642284 + 189 WP_000854559.1 cell division inhibition protein DicB -
SG49_RS08205 1642281..1642472 + 192 WP_001083297.1 lysis protein YdfD -
SG49_RS23690 1642565..1643332 + 768 Protein_1579 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1626109..1645195 19086


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T53887 WP_000323025.1 NZ_CP011321:c1638120-1637833 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T53887 NZ_CP011321:c1638120-1637833 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT53887 WP_000534858.1 NZ_CP011321:c1638359-1638120 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT53887 NZ_CP011321:c1638359-1638120 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References