272541

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 13545..14071 Replicon chromosome
Accession NZ_CP117962
Organism Escherichia coli strain JM109

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag PT299_RS01325 Protein ID WP_000323025.1
Coordinates 13784..14071 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag PT299_RS01320 Protein ID WP_000534858.1
Coordinates 13545..13784 (+) Length 80 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT299_RS01260 (8572) 8572..9339 - 768 Protein_10 exonuclease -
PT299_RS01265 (9432) 9432..9623 - 192 WP_001083297.1 lysis protein YdfD -
PT299_RS01270 (9620) 9620..9808 - 189 WP_000854559.1 cell division inhibition protein DicB -
PT299_RS01275 (10376) 10376..10594 - 219 WP_001171942.1 protein YdfC -
PT299_RS01280 (10624) 10624..10752 - 129 WP_000344964.1 protein YdfB -
PT299_RS01285 (10754) 10754..10909 - 156 WP_000379575.1 DUF1391 family protein -
PT299_RS01290 (11076) 11076..11483 - 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
PT299_RS01295 (11567) 11567..11797 + 231 WP_000920568.1 dicB transcriptional regulator DicC -
PT299_RS01300 (11781) 11781..12059 + 279 Protein_18 protein YdfX -
PT299_RS01305 (12094) 12094..12243 + 150 WP_011443592.1 protein YdfW -
PT299_RS01310 (12680) 12680..13012 - 333 WP_001301033.1 FlxA-like family protein -
PT299_RS01315 (13215) 13215..13520 - 306 WP_001326990.1 protein YdfV -
PT299_RS01320 (13545) 13545..13784 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
PT299_RS01325 (13784) 13784..14071 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
PT299_RS01330 (14143) 14143..14298 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
PT299_RS01335 (14515) 14515..14766 + 252 WP_000980994.1 protein Rem -
PT299_RS01340 (14833) 14833..15111 + 279 WP_012304870.1 hypothetical protein -
PT299_RS01345 (15113) 15113..16162 + 1050 WP_001265198.1 DUF968 domain-containing protein -
PT299_RS01350 (16176) 16176..16928 + 753 WP_001047135.1 antitermination protein -
PT299_RS01355 (17206) 17206..17295 - 90 WP_120795389.1 hypothetical protein -
PT299_RS01360 (17350) 17350..17562 - 213 WP_000087756.1 cold shock-like protein CspF -
PT299_RS01365 (17863) 17863..18078 + 216 WP_000066484.1 cold shock-like protein CspB -
PT299_RS01370 (18442) 18442..18612 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
PT299_RS01375 (18832) 18832..19047 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 6709..30202 23493


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T272541 WP_000323025.1 NZ_CP117962:13784-14071 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp


Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT272541 WP_000534858.1 NZ_CP117962:13545-13784 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9


Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References