60579

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1749515..1750041 Replicon chromosome
Accession NZ_CP014272
Organism Escherichia coli K-12 strain K-12 C3026

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag C3026_RS08995 Protein ID WP_000323025.1
Coordinates 1749515..1749802 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag C3026_RS09000 Protein ID WP_000534858.1
Coordinates 1749802..1750041 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C3026_RS08955 1744539..1744754 - 216 WP_000839590.1 phage lysis protein EssD -
C3026_RS28690 1744974..1745144 + 171 WP_211180497.1 putative zinc-binding protein YnfU -
C3026_RS08960 1745508..1745723 - 216 WP_000066484.1 cold shock-like protein CspB -
C3026_RS08965 1746024..1746236 + 213 WP_000087756.1 cold shock-like protein CspF -
C3026_RS28105 1746291..1746380 + 90 WP_120795389.1 hypothetical protein -
C3026_RS08970 1746658..1747410 - 753 WP_001047135.1 antitermination protein -
C3026_RS08975 1747424..1748473 - 1050 WP_001265198.1 DUF968 domain-containing protein -
C3026_RS08980 1748475..1748753 - 279 WP_012304870.1 hypothetical protein -
C3026_RS08985 1748820..1749071 - 252 WP_000980994.1 hypothetical protein -
C3026_RS08990 1749288..1749443 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
C3026_RS08995 1749515..1749802 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
C3026_RS09000 1749802..1750041 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
C3026_RS25810 1750066..1750371 + 306 WP_001326990.1 hypothetical protein -
C3026_RS09005 1750574..1750906 + 333 WP_001301033.1 protein FlxA -
C3026_RS09010 1751343..1751492 - 150 WP_011443592.1 hypothetical protein -
C3026_RS09015 1751527..1751805 - 279 Protein_1754 hypothetical protein -
C3026_RS09020 1751789..1752019 - 231 WP_000920568.1 dicB transcriptional regulator DicC -
C3026_RS09025 1752103..1752510 + 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
C3026_RS09030 1752677..1752832 + 156 WP_000379575.1 DUF1391 family protein -
C3026_RS09035 1752992..1753210 + 219 WP_001171942.1 hypothetical protein -
C3026_RS09045 1753778..1753966 + 189 WP_000854559.1 cell division inhibition protein DicB -
C3026_RS09050 1753963..1754154 + 192 WP_001083297.1 lysis protein YdfD -
C3026_RS25825 1754247..1755014 + 768 Protein_1761 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1735171..1759420 24249


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T60579 WP_000323025.1 NZ_CP014272:c1749802-1749515 [Escherichia coli K-12]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T60579 NZ_CP014272:c1749802-1749515 [Escherichia coli K-12]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT60579 WP_000534858.1 NZ_CP014272:c1750041-1749802 [Escherichia coli K-12]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT60579 NZ_CP014272:c1750041-1749802 [Escherichia coli K-12]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References