267002

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2285655..2286181 Replicon chromosome
Accession NZ_CP114895
Organism Escherichia coli strain CM56

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag O6106_RS11280 Protein ID WP_000323025.1
Coordinates 2285655..2285942 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag O6106_RS11285 Protein ID WP_000534858.1
Coordinates 2285942..2286181 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O6106_RS11230 (2280679) 2280679..2280894 - 216 WP_000839590.1 phage lysis protein EssD -
O6106_RS11235 (2281114) 2281114..2281284 + 171 WP_211180497.1 putative zinc-binding protein YnfU -
O6106_RS11240 (2281648) 2281648..2281863 - 216 WP_000066484.1 cold shock-like protein CspB -
O6106_RS11245 (2282164) 2282164..2282376 + 213 WP_000087756.1 cold shock-like protein CspF -
O6106_RS11250 (2282431) 2282431..2282520 + 90 WP_120795389.1 hypothetical protein -
O6106_RS11255 (2282798) 2282798..2283550 - 753 WP_001047135.1 antitermination protein -
O6106_RS11260 (2283564) 2283564..2284613 - 1050 WP_001265198.1 DUF968 domain-containing protein -
O6106_RS11265 (2284615) 2284615..2284893 - 279 WP_012304870.1 hypothetical protein -
O6106_RS11270 (2284960) 2284960..2285211 - 252 WP_000980994.1 protein Rem -
O6106_RS11275 (2285428) 2285428..2285583 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
O6106_RS11280 (2285655) 2285655..2285942 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
O6106_RS11285 (2285942) 2285942..2286181 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
O6106_RS11290 (2286206) 2286206..2286511 + 306 WP_001326990.1 protein YdfV -
O6106_RS11295 (2286714) 2286714..2287046 + 333 WP_001301033.1 FlxA-like family protein -
O6106_RS11300 (2287483) 2287483..2287632 - 150 WP_011443592.1 protein YdfW -
O6106_RS11305 (2287667) 2287667..2287945 - 279 Protein_2188 protein YdfX -
O6106_RS11310 (2287929) 2287929..2288159 - 231 WP_000920568.1 dicB transcriptional regulator DicC -
O6106_RS11315 (2288243) 2288243..2288650 + 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
O6106_RS11320 (2288817) 2288817..2288972 + 156 WP_000379575.1 DUF1391 family protein -
O6106_RS11325 (2288974) 2288974..2289102 + 129 WP_000344964.1 protein YdfB -
O6106_RS11330 (2289132) 2289132..2289350 + 219 WP_001171942.1 protein YdfC -
O6106_RS11335 (2289918) 2289918..2290106 + 189 WP_000854559.1 cell division inhibition protein DicB -
O6106_RS11340 (2290103) 2290103..2290294 + 192 WP_001083297.1 lysis protein YdfD -
O6106_RS11345 (2290387) 2290387..2291154 + 768 Protein_2196 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2271311..2294353 23042


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T267002 WP_000323025.1 NZ_CP114895:c2285942-2285655 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT267002 WP_000534858.1 NZ_CP114895:c2286181-2285942 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References