Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2233602..2234128 Replicon chromosome
Accession NZ_CP084209
Organism Escherichia coli strain EC2648-R2

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag LDB16_RS10790 Protein ID WP_000323025.1
Coordinates 2233841..2234128 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag LDB16_RS10785 Protein ID WP_000534858.1
Coordinates 2233602..2233841 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2222730..2250021 27291


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T218286 WP_000323025.1 NZ_CP084209:2233841-2234128 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T218286 NZ_CP115771:c23651-23370 [Paracoccus sediminicola]
ATGATTCAAAGCACCAAGGGCAAGCTGATCCAAGACATACTGGCGAACAAAGCCGGTAAAGGCTTCCCCGCCGGTATCAT
GAAAGTTGCCCGTCGAAAGCTGACCATGCTCGATGCGGCGAGCAAACTTGAGGATTTGCGCGTGCCACCAGCCAACCGGC
TTGAGGCGCTGCAAGGCGACCGAAAGGGGCAACACTCGATCCGGGTGAATGACCAATGGCGCTTCTGTTTCGTCTGGACC
GAAAGCGGTCCTGCTGATGTTGAGTTTACGGACTACCACTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT218286 WP_000534858.1 NZ_CP084209:2233602-2233841 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT218286 NZ_CP115771:c23358-23068 [Paracoccus sediminicola]
ATGGGACTTATGACCGACCCCTGCCACCCCGGCGAAATCCTCAAGCACGAATTTCTTGAGCCGCTTGGCGTTTCTGCGAT
TGGCCTGGCCAAGGTGATCGGCGTGCCGCGCACGCGCGTAGAACGGCTGGTGAAGGAACAAACCGCCGTGACCCCTGACA
CCGCTCTGCGTCTGTCCAAGGCTCTTGGGACAACCCCTGAATTTTGGATCAACATGCAGGCGAATTTTGACATGGCCTCT
GCCCGCAAGACTGTCGATGTCTCGGACATTGAGCCGCTTGTAGCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References