218286

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2233602..2234128 Replicon chromosome
Accession NZ_CP084209
Organism Escherichia coli strain EC2648-R2

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag LDB16_RS10790 Protein ID WP_000323025.1
Coordinates 2233841..2234128 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag LDB16_RS10785 Protein ID WP_000534858.1
Coordinates 2233602..2233841 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDB16_RS10730 (2228629) 2228629..2229396 - 768 Protein_2106 exonuclease -
LDB16_RS10735 (2229489) 2229489..2229680 - 192 WP_001083297.1 lysis protein YdfD -
LDB16_RS10740 (2229677) 2229677..2229865 - 189 WP_000854559.1 cell division inhibition protein DicB -
LDB16_RS10745 (2230433) 2230433..2230651 - 219 WP_001171942.1 protein YdfC -
LDB16_RS23315 (2230681) 2230681..2230809 - 129 WP_000344964.1 protein YdfB -
LDB16_RS10750 (2230811) 2230811..2230966 - 156 WP_000379575.1 DUF1391 family protein -
LDB16_RS10755 (2231133) 2231133..2231540 - 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
LDB16_RS10760 (2231624) 2231624..2231854 + 231 WP_000920568.1 dicB transcriptional regulator DicC -
LDB16_RS10765 (2231838) 2231838..2232116 + 279 Protein_2114 protein YdfX -
LDB16_RS10770 (2232151) 2232151..2232300 + 150 WP_011443592.1 protein YdfW -
LDB16_RS10775 (2232737) 2232737..2233069 - 333 WP_001301033.1 FlxA-like family protein -
LDB16_RS10780 (2233272) 2233272..2233577 - 306 WP_001326990.1 protein YdfV -
LDB16_RS10785 (2233602) 2233602..2233841 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
LDB16_RS10790 (2233841) 2233841..2234128 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
LDB16_RS10795 (2234200) 2234200..2234355 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
LDB16_RS10800 (2234572) 2234572..2234823 + 252 WP_000980994.1 protein Rem -
LDB16_RS10805 (2234890) 2234890..2235168 + 279 WP_012304870.1 hypothetical protein -
LDB16_RS10810 (2235170) 2235170..2236219 + 1050 WP_001265198.1 DUF968 domain-containing protein -
LDB16_RS10815 (2236233) 2236233..2236985 + 753 WP_001047135.1 antitermination protein -
LDB16_RS10820 (2237263) 2237263..2237352 - 90 WP_120795389.1 hypothetical protein -
LDB16_RS10825 (2237407) 2237407..2237619 - 213 WP_000087756.1 cold shock-like protein CspF -
LDB16_RS10830 (2237920) 2237920..2238135 + 216 WP_000066484.1 cold shock-like protein CspB -
LDB16_RS10835 (2238499) 2238499..2238669 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
LDB16_RS10840 (2238889) 2238889..2239104 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2222730..2250021 27291


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T218286 WP_000323025.1 NZ_CP084209:2233841-2234128 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T218286 NZ_CP115771:c23651-23370 [Paracoccus sediminicola]
ATGATTCAAAGCACCAAGGGCAAGCTGATCCAAGACATACTGGCGAACAAAGCCGGTAAAGGCTTCCCCGCCGGTATCAT
GAAAGTTGCCCGTCGAAAGCTGACCATGCTCGATGCGGCGAGCAAACTTGAGGATTTGCGCGTGCCACCAGCCAACCGGC
TTGAGGCGCTGCAAGGCGACCGAAAGGGGCAACACTCGATCCGGGTGAATGACCAATGGCGCTTCTGTTTCGTCTGGACC
GAAAGCGGTCCTGCTGATGTTGAGTTTACGGACTACCACTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT218286 WP_000534858.1 NZ_CP084209:2233602-2233841 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT218286 NZ_CP115771:c23358-23068 [Paracoccus sediminicola]
ATGGGACTTATGACCGACCCCTGCCACCCCGGCGAAATCCTCAAGCACGAATTTCTTGAGCCGCTTGGCGTTTCTGCGAT
TGGCCTGGCCAAGGTGATCGGCGTGCCGCGCACGCGCGTAGAACGGCTGGTGAAGGAACAAACCGCCGTGACCCCTGACA
CCGCTCTGCGTCTGTCCAAGGCTCTTGGGACAACCCCTGAATTTTGGATCAACATGCAGGCGAATTTTGACATGGCCTCT
GCCCGCAAGACTGTCGATGTCTCGGACATTGAGCCGCTTGTAGCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References