59671

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4238716..4239242 Replicon chromosome
Accession NZ_CP013952
Organism Escherichia coli strain HST04

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag AWH44_RS21900 Protein ID WP_000323025.1
Coordinates 4238955..4239242 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag AWH44_RS21895 Protein ID WP_000534858.1
Coordinates 4238716..4238955 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AWH44_RS21830 4233743..4234510 - 768 Protein_3966 exonuclease -
AWH44_RS21835 4234603..4234794 - 192 WP_001083297.1 lysis protein YdfD -
AWH44_RS21840 4234791..4234979 - 189 WP_000854559.1 cell division inhibition protein DicB -
AWH44_RS21850 4235547..4235765 - 219 WP_001171942.1 hypothetical protein -
AWH44_RS21860 4235925..4236080 - 156 WP_000379575.1 DUF1391 family protein -
AWH44_RS21865 4236247..4236654 - 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
AWH44_RS21870 4236738..4236968 + 231 WP_000920568.1 dicB transcriptional regulator DicC -
AWH44_RS21875 4236952..4237230 + 279 Protein_3973 hypothetical protein -
AWH44_RS21880 4237265..4237414 + 150 WP_011443592.1 hypothetical protein -
AWH44_RS21885 4237851..4238183 - 333 WP_001301033.1 protein FlxA -
AWH44_RS21890 4238386..4238691 - 306 WP_001326990.1 hypothetical protein -
AWH44_RS21895 4238716..4238955 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
AWH44_RS21900 4238955..4239242 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
AWH44_RS21905 4239314..4239469 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
AWH44_RS21910 4239686..4239937 + 252 WP_000980994.1 hypothetical protein -
AWH44_RS21915 4240004..4240282 + 279 WP_012304870.1 hypothetical protein -
AWH44_RS21920 4240284..4241333 + 1050 WP_001265198.1 DUF968 domain-containing protein -
AWH44_RS21925 4241347..4242099 + 753 WP_001047135.1 antitermination protein -
AWH44_RS23940 4242377..4242466 - 90 WP_120795389.1 hypothetical protein -
AWH44_RS21930 4242521..4242733 - 213 WP_000087756.1 cold shock-like protein CspF -
AWH44_RS21935 4243034..4243249 + 216 WP_000066484.1 cold shock-like protein CspB -
AWH44_RS24340 4243613..4243783 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
AWH44_RS21940 4244003..4244218 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 4226718..4253586 26868


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T59671 WP_000323025.1 NZ_CP013952:4238955-4239242 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T59671 NZ_CP013952:4238955-4239242 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT59671 WP_000534858.1 NZ_CP013952:4238716-4238955 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT59671 NZ_CP013952:4238716-4238955 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References