53930

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1637832..1638358 Replicon chromosome
Accession NZ_CP011322
Organism Escherichia coli strain SQ110

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag SG46_RS07995 Protein ID WP_000323025.1
Coordinates 1637832..1638119 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag SG46_RS08000 Protein ID WP_000534858.1
Coordinates 1638119..1638358 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SG46_RS07950 1632856..1633071 - 216 WP_000839590.1 phage lysis protein EssD -
SG46_RS07955 1633825..1634040 - 216 WP_000066484.1 cold shock-like protein CspB -
SG46_RS07960 1634341..1634553 + 213 WP_000087756.1 cold shock-like protein CspF -
SG46_RS07965 1634608..1634697 + 90 WP_120795389.1 hypothetical protein -
SG46_RS07970 1634975..1635727 - 753 WP_001047135.1 antitermination protein -
SG46_RS07975 1635741..1636790 - 1050 WP_001393597.1 DUF968 domain-containing protein -
SG46_RS07980 1636792..1637070 - 279 WP_012304870.1 hypothetical protein -
SG46_RS07985 1637137..1637388 - 252 WP_000980994.1 hypothetical protein -
SG46_RS07990 1637605..1637760 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
SG46_RS07995 1637832..1638119 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
SG46_RS08000 1638119..1638358 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
SG46_RS08005 1638383..1638688 + 306 WP_001326990.1 hypothetical protein -
SG46_RS08010 1638891..1639223 + 333 WP_001301033.1 protein FlxA -
SG46_RS08015 1639660..1639809 - 150 WP_011443592.1 hypothetical protein -
SG46_RS08020 1639844..1640122 - 279 Protein_1572 hypothetical protein -
SG46_RS08025 1640106..1640336 - 231 WP_000920568.1 dicB transcriptional regulator DicC -
SG46_RS08030 1640420..1640827 + 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
SG46_RS08035 1640994..1641149 + 156 WP_000379575.1 DUF1391 family protein -
SG46_RS08040 1641309..1641527 + 219 WP_001171942.1 hypothetical protein -
SG46_RS08045 1642095..1642283 + 189 WP_000854559.1 cell division inhibition protein DicB -
SG46_RS08050 1642280..1642471 + 192 WP_001083297.1 lysis protein YdfD -
SG46_RS08055 1642564..1643331 + 768 Protein_1579 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1626108..1645194 19086


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T53930 WP_000323025.1 NZ_CP011322:c1638119-1637832 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T53930 NZ_CP011322:c1638119-1637832 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT53930 WP_000534858.1 NZ_CP011322:c1638358-1638119 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT53930 NZ_CP011322:c1638358-1638119 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References