Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/ParE-RelB |
Location | 1643371..1643897 | Replicon | chromosome |
Accession | NZ_CP026028 | ||
Organism | Escherichia coli strain CIT |
Toxin (Protein)
Gene name | relE | Uniprot ID | S1EXL1 |
Locus tag | C2H83_RS08625 | Protein ID | WP_000323025.1 |
Coordinates | 1643371..1643658 (-) | Length | 96 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | S1F6D3 |
Locus tag | C2H83_RS08630 | Protein ID | WP_000534858.1 |
Coordinates | 1643658..1643897 (-) | Length | 80 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
C2H83_RS08585 | 1638395..1638610 | - | 216 | WP_000839590.1 | phage lysis protein EssD | - |
C2H83_RS24365 | 1638830..1639000 | + | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
C2H83_RS08590 | 1639364..1639579 | - | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
C2H83_RS08595 | 1639880..1640092 | + | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
C2H83_RS24095 | 1640147..1640236 | + | 90 | WP_120795389.1 | hypothetical protein | - |
C2H83_RS08600 | 1640514..1641266 | - | 753 | WP_001047135.1 | antitermination protein | - |
C2H83_RS08605 | 1641280..1642329 | - | 1050 | WP_001393597.1 | DUF968 domain-containing protein | - |
C2H83_RS08610 | 1642331..1642609 | - | 279 | WP_012304870.1 | hypothetical protein | - |
C2H83_RS08615 | 1642676..1642927 | - | 252 | WP_000980994.1 | hypothetical protein | - |
C2H83_RS08620 | 1643144..1643299 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
C2H83_RS08625 | 1643371..1643658 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
C2H83_RS08630 | 1643658..1643897 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
C2H83_RS08635 | 1643922..1644227 | + | 306 | WP_001326990.1 | hypothetical protein | - |
C2H83_RS08640 | 1644430..1644762 | + | 333 | WP_001301033.1 | protein FlxA | - |
C2H83_RS24100 | 1645199..1645348 | - | 150 | WP_011443592.1 | hypothetical protein | - |
C2H83_RS08650 | 1645383..1645661 | - | 279 | Protein_1581 | hypothetical protein | - |
C2H83_RS08655 | 1645645..1645875 | - | 231 | WP_000920568.1 | dicB transcriptional regulator DicC | - |
C2H83_RS08660 | 1645959..1646366 | + | 408 | WP_000448564.1 | DNA-binding transcriptional dual regulator DicA | - |
C2H83_RS08665 | 1646533..1646688 | + | 156 | WP_000379575.1 | DUF1391 family protein | - |
C2H83_RS08675 | 1646848..1647066 | + | 219 | WP_001171942.1 | hypothetical protein | - |
C2H83_RS08685 | 1647634..1647822 | + | 189 | WP_000854559.1 | cell division inhibition protein DicB | - |
C2H83_RS08690 | 1647819..1648010 | + | 192 | WP_001083297.1 | lysis protein YdfD | - |
C2H83_RS08695 | 1648103..1648870 | + | 768 | Protein_1588 | exonuclease | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Prophage | - | - | 1629027..1650733 | 21706 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T92846 WP_000323025.1 NZ_CP026028:c1643658-1643371 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T92846 NZ_CP026028:c1643658-1643371 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT92846 WP_000534858.1 NZ_CP026028:c1643897-1643658 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT92846 NZ_CP026028:c1643897-1643658 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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