Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2241089..2241615 Replicon chromosome
Accession NZ_CP042865
Organism Escherichia coli strain ATCC BAA-196

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag BAA196NC_RS10870 Protein ID WP_000323025.1
Coordinates 2241328..2241615 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag BAA196NC_RS10865 Protein ID WP_000534858.1
Coordinates 2241089..2241328 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BAA196NC_RS10805 2236116..2236883 - 768 Protein_2104 exonuclease -
BAA196NC_RS10810 2236976..2237167 - 192 WP_001083297.1 lysis protein YdfD -
BAA196NC_RS10815 2237164..2237352 - 189 WP_000854559.1 cell division inhibition protein DicB -
BAA196NC_RS10825 2237920..2238138 - 219 WP_001171942.1 hypothetical protein -
BAA196NC_RS10830 2238298..2238453 - 156 WP_000379575.1 DUF1391 family protein -
BAA196NC_RS10835 2238620..2239027 - 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
BAA196NC_RS10840 2239111..2239341 + 231 WP_000920568.1 dicB transcriptional regulator DicC -
BAA196NC_RS10845 2239325..2239603 + 279 Protein_2111 hypothetical protein -
BAA196NC_RS10850 2239638..2239787 + 150 WP_011443592.1 hypothetical protein -
BAA196NC_RS10855 2240224..2240556 - 333 WP_001301033.1 protein FlxA -
BAA196NC_RS10860 2240759..2241064 - 306 WP_001326990.1 hypothetical protein -
BAA196NC_RS10865 2241089..2241328 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
BAA196NC_RS10870 2241328..2241615 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
BAA196NC_RS10875 2241687..2241842 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
BAA196NC_RS10880 2242059..2242310 + 252 WP_000980994.1 hypothetical protein -
BAA196NC_RS10885 2242377..2242655 + 279 WP_012304870.1 hypothetical protein -
BAA196NC_RS10890 2242657..2243706 + 1050 WP_001265198.1 DUF968 domain-containing protein -
BAA196NC_RS10895 2243720..2244472 + 753 WP_001047135.1 antitermination protein -
BAA196NC_RS10900 2244750..2244839 - 90 WP_120795389.1 hypothetical protein -
BAA196NC_RS10905 2244894..2245106 - 213 WP_000087756.1 cold shock-like protein CspF -
BAA196NC_RS10910 2245407..2245622 + 216 WP_000066484.1 cold shock-like protein CspB -
BAA196NC_RS24525 2245986..2246156 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
BAA196NC_RS10915 2246376..2246591 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2229091..2255959 26868


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T136307 WP_000323025.1 NZ_CP042865:2241328-2241615 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T136307 NZ_CP042865:2241328-2241615 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT136307 WP_000534858.1 NZ_CP042865:2241089-2241328 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT136307 NZ_CP042865:2241089-2241328 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References