136307

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2241089..2241615 Replicon chromosome
Accession NZ_CP042865
Organism Escherichia coli strain ATCC BAA-196

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag BAA196NC_RS10870 Protein ID WP_000323025.1
Coordinates 2241328..2241615 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag BAA196NC_RS10865 Protein ID WP_000534858.1
Coordinates 2241089..2241328 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BAA196NC_RS10805 2236116..2236883 - 768 Protein_2104 exonuclease -
BAA196NC_RS10810 2236976..2237167 - 192 WP_001083297.1 lysis protein YdfD -
BAA196NC_RS10815 2237164..2237352 - 189 WP_000854559.1 cell division inhibition protein DicB -
BAA196NC_RS10825 2237920..2238138 - 219 WP_001171942.1 hypothetical protein -
BAA196NC_RS10830 2238298..2238453 - 156 WP_000379575.1 DUF1391 family protein -
BAA196NC_RS10835 2238620..2239027 - 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
BAA196NC_RS10840 2239111..2239341 + 231 WP_000920568.1 dicB transcriptional regulator DicC -
BAA196NC_RS10845 2239325..2239603 + 279 Protein_2111 hypothetical protein -
BAA196NC_RS10850 2239638..2239787 + 150 WP_011443592.1 hypothetical protein -
BAA196NC_RS10855 2240224..2240556 - 333 WP_001301033.1 protein FlxA -
BAA196NC_RS10860 2240759..2241064 - 306 WP_001326990.1 hypothetical protein -
BAA196NC_RS10865 2241089..2241328 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
BAA196NC_RS10870 2241328..2241615 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
BAA196NC_RS10875 2241687..2241842 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
BAA196NC_RS10880 2242059..2242310 + 252 WP_000980994.1 hypothetical protein -
BAA196NC_RS10885 2242377..2242655 + 279 WP_012304870.1 hypothetical protein -
BAA196NC_RS10890 2242657..2243706 + 1050 WP_001265198.1 DUF968 domain-containing protein -
BAA196NC_RS10895 2243720..2244472 + 753 WP_001047135.1 antitermination protein -
BAA196NC_RS10900 2244750..2244839 - 90 WP_120795389.1 hypothetical protein -
BAA196NC_RS10905 2244894..2245106 - 213 WP_000087756.1 cold shock-like protein CspF -
BAA196NC_RS10910 2245407..2245622 + 216 WP_000066484.1 cold shock-like protein CspB -
BAA196NC_RS24525 2245986..2246156 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
BAA196NC_RS10915 2246376..2246591 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2229091..2255959 26868


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T136307 WP_000323025.1 NZ_CP042865:2241328-2241615 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T136307 NZ_CP042865:2241328-2241615 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT136307 WP_000534858.1 NZ_CP042865:2241089-2241328 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT136307 NZ_CP042865:2241089-2241328 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References