199413

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2240138..2240664 Replicon chromosome
Accession NZ_CP072986
Organism Escherichia coli strain T159A

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag KBW97_RS10770 Protein ID WP_000323025.1
Coordinates 2240377..2240664 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag KBW97_RS10765 Protein ID WP_000534858.1
Coordinates 2240138..2240377 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KBW97_RS10710 (2235165) 2235165..2235932 - 768 Protein_2113 exonuclease -
KBW97_RS10715 (2236025) 2236025..2236216 - 192 WP_001083297.1 lysis protein YdfD -
KBW97_RS10720 (2236213) 2236213..2236401 - 189 WP_000854559.1 cell division inhibition protein DicB -
KBW97_RS10725 (2236969) 2236969..2237187 - 219 WP_001171942.1 protein YdfC -
KBW97_RS23475 (2237217) 2237217..2237345 - 129 WP_000344964.1 protein YdfB -
KBW97_RS10730 (2237347) 2237347..2237502 - 156 WP_000379575.1 DUF1391 family protein -
KBW97_RS10735 (2237669) 2237669..2238076 - 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
KBW97_RS10740 (2238160) 2238160..2238390 + 231 WP_000920568.1 dicB transcriptional regulator DicC -
KBW97_RS10745 (2238374) 2238374..2238652 + 279 Protein_2121 protein YdfX -
KBW97_RS10750 (2238687) 2238687..2238836 + 150 WP_011443592.1 protein YdfW -
KBW97_RS10755 (2239273) 2239273..2239605 - 333 WP_001301033.1 FlxA-like family protein -
KBW97_RS10760 (2239808) 2239808..2240113 - 306 WP_001326990.1 protein YdfV -
KBW97_RS10765 (2240138) 2240138..2240377 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
KBW97_RS10770 (2240377) 2240377..2240664 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
KBW97_RS10775 (2240736) 2240736..2240891 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
KBW97_RS10780 (2241108) 2241108..2241359 + 252 WP_000980994.1 protein Rem -
KBW97_RS10785 (2241426) 2241426..2241704 + 279 WP_012304870.1 hypothetical protein -
KBW97_RS10790 (2241706) 2241706..2242755 + 1050 WP_001265198.1 DUF968 domain-containing protein -
KBW97_RS10795 (2242769) 2242769..2243521 + 753 WP_001047135.1 antitermination protein -
KBW97_RS10800 (2243799) 2243799..2243888 - 90 WP_120795389.1 hypothetical protein -
KBW97_RS10805 (2243943) 2243943..2244155 - 213 WP_000087756.1 cold shock-like protein CspF -
KBW97_RS10810 (2244456) 2244456..2244671 + 216 WP_000066484.1 cold shock-like protein CspB -
KBW97_RS23195 (2245035) 2245035..2245205 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
KBW97_RS10815 (2245425) 2245425..2245640 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2233302..2255008 21706


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T199413 WP_000323025.1 NZ_CP072986:2240377-2240664 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T199413 NZ_CP097338:c77630-77202 [Mannheimia haemolytica]
ATGTATCGCTACCTTTTTGATACCAATATAGTTTCCGAGCTTTATAAGTTAAGAAATGACAAGATGGATGTCAATGTTCG
CCAGTGGCTGAGAGGGGTTAATCCTAGCCAGACCAATATCAGCTGTATTACGTTATCTGAAATCAAAACAGGTATTTTGC
TGAAAGCCCGCAAAGACAAAGAACAATCAGACCGATTAAATGATTGGTTTGAAAATAATGTATTAAAGGCTTATCAAACA
AAAGCGTTTGTGGTGAATAACGACATTGCTCTATTGGCATCAGAGTACCATATTCCCAATAAAATGGATTTAAATGATGC
TTATATTGCGGCAACCGCCAAATACCACAATCTGATTTTAGTCACCCGCAACACCAAAGATTTTATCCGTTGTGATGTGC
GTTTATTTAACCCATTTGAAACCGCATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT199413 WP_000534858.1 NZ_CP072986:2240138-2240377 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT199413 NZ_CP097338:c77917-77630 [Mannheimia haemolytica]
ATGGCAATAACCATTACTTCCAGAGAATTTAATCAAAATGCCAGCAAAGTGTTAAAAATGGCAGAAAAAGAGCCGGTTTT
TATTACCAAATGGGGCAAAATCGTCAATGTGGTGTCTAGTTATATGGATTATCAGCAGAAAAAGCCTAGCGAGCCAAGCT
TTGAAGAGCTATTCGCCTCTTCCGAAAATGAGGATGTGAGCGATGAATTTTGGCAAGAGTTTGAACAAACATTGGTTGAA
ATCCGCAAAAGCAATAAACCAAGACCTGTTGATTTTGGAGATGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References