209827

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2236080..2236606 Replicon chromosome
Accession NZ_CP079735
Organism Escherichia coli strain GB2005

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag KYX12_RS10825 Protein ID WP_000323025.1
Coordinates 2236319..2236606 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag KYX12_RS10820 Protein ID WP_000534858.1
Coordinates 2236080..2236319 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYX12_RS10765 (2231107) 2231107..2231874 - 768 Protein_2105 exonuclease -
KYX12_RS10770 (2231967) 2231967..2232158 - 192 WP_001083297.1 lysis protein YdfD -
KYX12_RS10775 (2232155) 2232155..2232343 - 189 WP_000854559.1 cell division inhibition protein DicB -
KYX12_RS10780 (2232911) 2232911..2233129 - 219 WP_001171942.1 protein YdfC -
KYX12_RS22200 (2233159) 2233159..2233287 - 129 WP_000344964.1 protein YdfB -
KYX12_RS10785 (2233289) 2233289..2233444 - 156 WP_000379575.1 DUF1391 family protein -
KYX12_RS10790 (2233611) 2233611..2234018 - 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
KYX12_RS10795 (2234102) 2234102..2234332 + 231 WP_000920568.1 dicB transcriptional regulator DicC -
KYX12_RS10800 (2234316) 2234316..2234594 + 279 Protein_2113 hypothetical protein -
KYX12_RS10805 (2234629) 2234629..2234778 + 150 WP_011443592.1 protein YdfW -
KYX12_RS10810 (2235215) 2235215..2235547 - 333 WP_001301033.1 FlxA-like family protein -
KYX12_RS10815 (2235750) 2235750..2236055 - 306 WP_001326990.1 protein YdfV -
KYX12_RS10820 (2236080) 2236080..2236319 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
KYX12_RS10825 (2236319) 2236319..2236606 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
KYX12_RS10830 (2236678) 2236678..2236833 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
KYX12_RS10835 (2237050) 2237050..2237301 + 252 WP_000980994.1 protein Rem -
KYX12_RS10840 (2237368) 2237368..2237646 + 279 WP_012304870.1 hypothetical protein -
KYX12_RS10845 (2237648) 2237648..2238697 + 1050 WP_001265198.1 DUF968 domain-containing protein -
KYX12_RS10850 (2238711) 2238711..2239463 + 753 WP_001047135.1 antitermination protein -
KYX12_RS10855 (2239741) 2239741..2239830 - 90 WP_120795389.1 hypothetical protein -
KYX12_RS10860 (2239885) 2239885..2240097 - 213 WP_000087756.1 cold shock-like protein CspF -
KYX12_RS10865 (2240398) 2240398..2240613 + 216 WP_000066484.1 cold shock-like protein CspB -
KYX12_RS10870 (2240977) 2240977..2241147 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
KYX12_RS10875 (2241367) 2241367..2241582 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2227908..2250948 23040


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T209827 WP_000323025.1 NZ_CP079735:2236319-2236606 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T209827 NZ_CP104326:973999-974334 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT209827 WP_000534858.1 NZ_CP079735:2236080-2236319 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT209827 NZ_CP104326:973751-973999 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References