Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1592242..1592768 Replicon chromosome
Accession NZ_CP053607
Organism Escherichia coli strain NEB5-alpha_F'Iq

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag HO392_RS07800 Protein ID WP_000323025.1
Coordinates 1592242..1592529 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag HO392_RS07805 Protein ID WP_000534858.1
Coordinates 1592529..1592768 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HO392_RS07750 1587267..1587482 - 216 WP_000839590.1 phage lysis protein EssD -
HO392_RS07755 1588236..1588451 - 216 WP_000066484.1 cold shock-like protein CspB -
HO392_RS07760 1588752..1588964 + 213 WP_000087756.1 cold shock-like protein CspF -
HO392_RS07765 1589019..1589108 + 90 WP_120795389.1 hypothetical protein -
HO392_RS07770 1589199..1589384 - 186 WP_151275831.1 hypothetical protein -
HO392_RS07775 1589385..1590137 - 753 WP_001047135.1 antitermination protein -
HO392_RS07780 1590151..1591200 - 1050 WP_001265198.1 DUF968 domain-containing protein -
HO392_RS07785 1591202..1591480 - 279 WP_012304870.1 hypothetical protein -
HO392_RS07790 1591547..1591798 - 252 WP_000980994.1 hypothetical protein -
HO392_RS07795 1592015..1592170 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
HO392_RS07800 1592242..1592529 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
HO392_RS07805 1592529..1592768 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
HO392_RS07810 1592793..1593098 + 306 WP_001326990.1 hypothetical protein -
HO392_RS07815 1593301..1593633 + 333 WP_001301033.1 protein FlxA -
HO392_RS07820 1594070..1594219 - 150 WP_011443592.1 hypothetical protein -
HO392_RS07825 1594254..1594532 - 279 Protein_1532 hypothetical protein -
HO392_RS07830 1594516..1594746 - 231 WP_000920568.1 dicB transcriptional regulator DicC -
HO392_RS07835 1594830..1595237 + 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
HO392_RS07840 1595404..1595559 + 156 WP_000379575.1 DUF1391 family protein -
HO392_RS07845 1595719..1595937 + 219 WP_001171942.1 hypothetical protein -
HO392_RS07855 1596505..1596693 + 189 WP_000854559.1 cell division inhibition protein DicB -
HO392_RS07860 1596690..1596881 + 192 WP_001083297.1 lysis protein YdfD -
HO392_RS07865 1596974..1597741 + 768 Protein_1539 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1577899..1599604 21705


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T157177 WP_000323025.1 NZ_CP053607:c1592529-1592242 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T157177 NZ_CP069077:c3076985-3076590 [Mycobacterium tuberculosis]
GTGATCGTCGATACGTCGGCCATCGTCGCCATCGTGAGCGGGGAATCGGGCGCGCAGGTGCTCAAGGAGGCGCTGGAGCG
GTCACCGAACTCCCGAATGTCCGCGCCCAACTACGTCGAACTGTGCGCGATCATGCAGCGGCGGGACCGGCCGGAGATCT
CTCGATTGGTGGACCGTTTGCTGGACGACTACGGAATCCAGGTCGAAGCCGTCGACGCCGACCAAGCCCGCGTGGCCGCG
CAGGCGTATCGCGACTACGGCCGCGGCAGCGGCCATCCGGCCCGTCTCAACCTCGGCGACACCTACAGCTACGCCCTGGC
CCAGGTCACCGGGGAGCCGCTGCTGTTTCGTGGCGATGACTTCACGCATACCGATATCCGGCCCGCGTGCACCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT157177 WP_000534858.1 NZ_CP053607:c1592768-1592529 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT157177 NZ_CP069077:c3076564-3076298 [Mycobacterium tuberculosis]
ATGCATCGCGGATATGCATTAGTAGTATGCTCTCCGGGTGTGACGCGCACCATGATCGACATCGATGACGACCTGCTCGC
TCGGGCCGCCAAGGAACTGGGTACCACGACAAAGAAAGACACCGTGCATGCCGCGCTGCGGGCCGCGTTGCGAGCCAGTG
CCGCGCGCTCGCTCATGAACCGGATGGCCGAGAACGCCACCGGAACCCAGGACGAAGCTCTGGTCAACGCAATGTGGCGA
GACGGCCACCCAGAGAACACGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References