157177

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1592242..1592768 Replicon chromosome
Accession NZ_CP053607
Organism Escherichia coli strain NEB5-alpha_F'Iq

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag HO392_RS07800 Protein ID WP_000323025.1
Coordinates 1592242..1592529 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag HO392_RS07805 Protein ID WP_000534858.1
Coordinates 1592529..1592768 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HO392_RS07750 1587267..1587482 - 216 WP_000839590.1 phage lysis protein EssD -
HO392_RS07755 1588236..1588451 - 216 WP_000066484.1 cold shock-like protein CspB -
HO392_RS07760 1588752..1588964 + 213 WP_000087756.1 cold shock-like protein CspF -
HO392_RS07765 1589019..1589108 + 90 WP_120795389.1 hypothetical protein -
HO392_RS07770 1589199..1589384 - 186 WP_151275831.1 hypothetical protein -
HO392_RS07775 1589385..1590137 - 753 WP_001047135.1 antitermination protein -
HO392_RS07780 1590151..1591200 - 1050 WP_001265198.1 DUF968 domain-containing protein -
HO392_RS07785 1591202..1591480 - 279 WP_012304870.1 hypothetical protein -
HO392_RS07790 1591547..1591798 - 252 WP_000980994.1 hypothetical protein -
HO392_RS07795 1592015..1592170 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
HO392_RS07800 1592242..1592529 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
HO392_RS07805 1592529..1592768 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
HO392_RS07810 1592793..1593098 + 306 WP_001326990.1 hypothetical protein -
HO392_RS07815 1593301..1593633 + 333 WP_001301033.1 protein FlxA -
HO392_RS07820 1594070..1594219 - 150 WP_011443592.1 hypothetical protein -
HO392_RS07825 1594254..1594532 - 279 Protein_1532 hypothetical protein -
HO392_RS07830 1594516..1594746 - 231 WP_000920568.1 dicB transcriptional regulator DicC -
HO392_RS07835 1594830..1595237 + 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
HO392_RS07840 1595404..1595559 + 156 WP_000379575.1 DUF1391 family protein -
HO392_RS07845 1595719..1595937 + 219 WP_001171942.1 hypothetical protein -
HO392_RS07855 1596505..1596693 + 189 WP_000854559.1 cell division inhibition protein DicB -
HO392_RS07860 1596690..1596881 + 192 WP_001083297.1 lysis protein YdfD -
HO392_RS07865 1596974..1597741 + 768 Protein_1539 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1577899..1599604 21705


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T157177 WP_000323025.1 NZ_CP053607:c1592529-1592242 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T157177 NZ_CP069077:c3076985-3076590 [Mycobacterium tuberculosis]
GTGATCGTCGATACGTCGGCCATCGTCGCCATCGTGAGCGGGGAATCGGGCGCGCAGGTGCTCAAGGAGGCGCTGGAGCG
GTCACCGAACTCCCGAATGTCCGCGCCCAACTACGTCGAACTGTGCGCGATCATGCAGCGGCGGGACCGGCCGGAGATCT
CTCGATTGGTGGACCGTTTGCTGGACGACTACGGAATCCAGGTCGAAGCCGTCGACGCCGACCAAGCCCGCGTGGCCGCG
CAGGCGTATCGCGACTACGGCCGCGGCAGCGGCCATCCGGCCCGTCTCAACCTCGGCGACACCTACAGCTACGCCCTGGC
CCAGGTCACCGGGGAGCCGCTGCTGTTTCGTGGCGATGACTTCACGCATACCGATATCCGGCCCGCGTGCACCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT157177 WP_000534858.1 NZ_CP053607:c1592768-1592529 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT157177 NZ_CP069077:c3076564-3076298 [Mycobacterium tuberculosis]
ATGCATCGCGGATATGCATTAGTAGTATGCTCTCCGGGTGTGACGCGCACCATGATCGACATCGATGACGACCTGCTCGC
TCGGGCCGCCAAGGAACTGGGTACCACGACAAAGAAAGACACCGTGCATGCCGCGCTGCGGGCCGCGTTGCGAGCCAGTG
CCGCGCGCTCGCTCATGAACCGGATGGCCGAGAACGCCACCGGAACCCAGGACGAAGCTCTGGTCAACGCAATGTGGCGA
GACGGCCACCCAGAGAACACGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References