Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1649000..1649526 Replicon chromosome
Accession NZ_LT615377
Organism Escherichia coli isolate 106

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag BV315_RS08865 Protein ID WP_000323025.1
Coordinates 1649000..1649287 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag BV315_RS08870 Protein ID WP_000534858.1
Coordinates 1649287..1649526 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BV315_RS08825 1644024..1644239 - 216 WP_000839590.1 phage lysis protein EssD -
BV315_RS25565 1644459..1644629 + 171 WP_211180497.1 putative zinc-binding protein YnfU -
BV315_RS08830 1644993..1645208 - 216 WP_000066484.1 cold shock-like protein CspB -
BV315_RS08835 1645509..1645721 + 213 WP_000087756.1 cold shock-like protein CspF -
BV315_RS25120 1645776..1645865 + 90 WP_120795389.1 hypothetical protein -
BV315_RS08840 1646143..1646895 - 753 WP_001047135.1 antitermination protein -
BV315_RS08845 1646909..1647958 - 1050 WP_001265198.1 DUF968 domain-containing protein -
BV315_RS08850 1647960..1648238 - 279 WP_012304870.1 hypothetical protein -
BV315_RS08855 1648305..1648556 - 252 WP_000980994.1 hypothetical protein -
BV315_RS08860 1648773..1648928 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
BV315_RS08865 1649000..1649287 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
BV315_RS08870 1649287..1649526 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
BV315_RS08875 1649551..1649856 + 306 WP_001326990.1 hypothetical protein -
BV315_RS08885 1650059..1650391 + 333 WP_001301033.1 protein FlxA -
BV315_RS08890 1650828..1650977 - 150 WP_011443592.1 hypothetical protein -
BV315_RS08895 1651012..1651290 - 279 Protein_1589 hypothetical protein -
BV315_RS08900 1651274..1651504 - 231 WP_000920568.1 dicB transcriptional regulator DicC -
BV315_RS08905 1651588..1651995 + 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
BV315_RS08910 1652162..1652317 + 156 WP_000379575.1 DUF1391 family protein -
BV315_RS08920 1652477..1652695 + 219 WP_001171942.1 hypothetical protein -
BV315_RS08930 1653263..1653451 + 189 WP_000854559.1 cell division inhibition protein DicB -
BV315_RS08935 1653448..1653639 + 192 WP_001083297.1 lysis protein YdfD -
BV315_RS08940 1653732..1654499 + 768 Protein_1596 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1634656..1668117 33461


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T293343 WP_000323025.1 NZ_LT615377:c1649287-1649000 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT293343 WP_000534858.1 NZ_LT615377:c1649526-1649287 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References