137410

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2238803..2239329 Replicon chromosome
Accession NZ_CP043183
Organism Escherichia coli O16:H48 strain PG20180172

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag FYA19_RS10845 Protein ID WP_000323025.1
Coordinates 2239042..2239329 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag FYA19_RS10840 Protein ID WP_000534858.1
Coordinates 2238803..2239042 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYA19_RS10780 2233830..2234597 - 768 Protein_2099 exonuclease -
FYA19_RS10785 2234690..2234881 - 192 WP_001083297.1 lysis protein YdfD -
FYA19_RS10790 2234878..2235066 - 189 WP_000854559.1 cell division inhibition protein DicB -
FYA19_RS10800 2235634..2235852 - 219 WP_001171942.1 hypothetical protein -
FYA19_RS10805 2236012..2236167 - 156 WP_000379575.1 DUF1391 family protein -
FYA19_RS10810 2236334..2236741 - 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
FYA19_RS10815 2236825..2237055 + 231 WP_000920568.1 dicB transcriptional regulator DicC -
FYA19_RS10820 2237039..2237317 + 279 Protein_2106 hypothetical protein -
FYA19_RS10825 2237352..2237501 + 150 WP_011443592.1 hypothetical protein -
FYA19_RS10830 2237938..2238270 - 333 WP_001301033.1 protein FlxA -
FYA19_RS10835 2238473..2238778 - 306 WP_001326990.1 hypothetical protein -
FYA19_RS10840 2238803..2239042 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
FYA19_RS10845 2239042..2239329 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
FYA19_RS10850 2239401..2239556 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
FYA19_RS10855 2239773..2240024 + 252 WP_000980994.1 hypothetical protein -
FYA19_RS10860 2240091..2240369 + 279 WP_012304870.1 hypothetical protein -
FYA19_RS10865 2240371..2241420 + 1050 WP_001265198.1 DUF968 domain-containing protein -
FYA19_RS10870 2241434..2242186 + 753 WP_001047135.1 antitermination protein -
FYA19_RS10875 2242464..2242553 - 90 WP_120795389.1 hypothetical protein -
FYA19_RS10880 2242608..2242820 - 213 WP_000087756.1 cold shock-like protein CspF -
FYA19_RS10885 2243121..2243336 + 216 WP_000066484.1 cold shock-like protein CspB -
FYA19_RS23170 2243700..2243870 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
FYA19_RS10890 2244090..2244305 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2220212..2253673 33461


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T137410 WP_000323025.1 NZ_CP043183:2239042-2239329 [Escherichia coli O16:H48]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T137410 NZ_CP056720:9554-9970 [Enterobacter hormaechei]
GTGAACAAGATCTATATGCTCGACACCAACATCTGCTCGTTCATCATGCGCGAGCAGCCTGAAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGTGGCCACCGTATCGTGGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGTGCCACCGGCC
CGAAGGCCTCGCCGCGCCACGTCCAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGACCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGCCTCGCCGGAACGCCGATAGGCCCGAACGACACGGCGATCGC
CGGGCATGCCATTGCGGCCGGCGCCGTACTGGTGACAAATAATGTGCGGGAGTTTGAGCGGGTGCCGGATCTGGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT137410 WP_000534858.1 NZ_CP043183:2238803-2239042 [Escherichia coli O16:H48]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT137410 NZ_CP056720:9327-9557 [Enterobacter hormaechei]
ATGAGAACCGTATCTATTTTTAAAAACGGCAACAACCGCGCCATCCGCCTTCCCCGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGTCCCGTCCGGCCGACCTGGGGGTCGTTCGCGCAGCTCG
AAAAAGCCGATCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGAAGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References