Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2238803..2239329 Replicon chromosome
Accession NZ_CP043183
Organism Escherichia coli O16:H48 strain PG20180172

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag FYA19_RS10845 Protein ID WP_000323025.1
Coordinates 2239042..2239329 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag FYA19_RS10840 Protein ID WP_000534858.1
Coordinates 2238803..2239042 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYA19_RS10780 2233830..2234597 - 768 Protein_2099 exonuclease -
FYA19_RS10785 2234690..2234881 - 192 WP_001083297.1 lysis protein YdfD -
FYA19_RS10790 2234878..2235066 - 189 WP_000854559.1 cell division inhibition protein DicB -
FYA19_RS10800 2235634..2235852 - 219 WP_001171942.1 hypothetical protein -
FYA19_RS10805 2236012..2236167 - 156 WP_000379575.1 DUF1391 family protein -
FYA19_RS10810 2236334..2236741 - 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
FYA19_RS10815 2236825..2237055 + 231 WP_000920568.1 dicB transcriptional regulator DicC -
FYA19_RS10820 2237039..2237317 + 279 Protein_2106 hypothetical protein -
FYA19_RS10825 2237352..2237501 + 150 WP_011443592.1 hypothetical protein -
FYA19_RS10830 2237938..2238270 - 333 WP_001301033.1 protein FlxA -
FYA19_RS10835 2238473..2238778 - 306 WP_001326990.1 hypothetical protein -
FYA19_RS10840 2238803..2239042 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
FYA19_RS10845 2239042..2239329 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
FYA19_RS10850 2239401..2239556 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
FYA19_RS10855 2239773..2240024 + 252 WP_000980994.1 hypothetical protein -
FYA19_RS10860 2240091..2240369 + 279 WP_012304870.1 hypothetical protein -
FYA19_RS10865 2240371..2241420 + 1050 WP_001265198.1 DUF968 domain-containing protein -
FYA19_RS10870 2241434..2242186 + 753 WP_001047135.1 antitermination protein -
FYA19_RS10875 2242464..2242553 - 90 WP_120795389.1 hypothetical protein -
FYA19_RS10880 2242608..2242820 - 213 WP_000087756.1 cold shock-like protein CspF -
FYA19_RS10885 2243121..2243336 + 216 WP_000066484.1 cold shock-like protein CspB -
FYA19_RS23170 2243700..2243870 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
FYA19_RS10890 2244090..2244305 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2220212..2253673 33461


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T137410 WP_000323025.1 NZ_CP043183:2239042-2239329 [Escherichia coli O16:H48]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T137410 NZ_CP056720:9554-9970 [Enterobacter hormaechei]
GTGAACAAGATCTATATGCTCGACACCAACATCTGCTCGTTCATCATGCGCGAGCAGCCTGAAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGTGGCCACCGTATCGTGGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGTGCCACCGGCC
CGAAGGCCTCGCCGCGCCACGTCCAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGACCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGCCTCGCCGGAACGCCGATAGGCCCGAACGACACGGCGATCGC
CGGGCATGCCATTGCGGCCGGCGCCGTACTGGTGACAAATAATGTGCGGGAGTTTGAGCGGGTGCCGGATCTGGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT137410 WP_000534858.1 NZ_CP043183:2238803-2239042 [Escherichia coli O16:H48]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT137410 NZ_CP056720:9327-9557 [Enterobacter hormaechei]
ATGAGAACCGTATCTATTTTTAAAAACGGCAACAACCGCGCCATCCGCCTTCCCCGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGTCCCGTCCGGCCGACCTGGGGGTCGTTCGCGCAGCTCG
AAAAAGCCGATCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGAAGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References