204590

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1175498..1176024 Replicon chromosome
Accession NZ_CP076043
Organism Escherichia coli strain Stbl4

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag ITN70_RS05795 Protein ID WP_000323025.1
Coordinates 1175737..1176024 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag ITN70_RS05790 Protein ID WP_000534858.1
Coordinates 1175498..1175737 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ITN70_RS05735 (1170525) 1170525..1171292 - 768 Protein_1118 exonuclease -
ITN70_RS05740 (1171385) 1171385..1171576 - 192 WP_001083297.1 lysis protein YdfD -
ITN70_RS05745 (1171573) 1171573..1171761 - 189 WP_000854559.1 cell division inhibition protein DicB -
ITN70_RS05750 (1172329) 1172329..1172547 - 219 WP_001171942.1 protein YdfC -
ITN70_RS21900 (1172577) 1172577..1172705 - 129 WP_000344964.1 protein YdfB -
ITN70_RS05755 (1172707) 1172707..1172862 - 156 WP_000379575.1 DUF1391 family protein -
ITN70_RS05760 (1173029) 1173029..1173436 - 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
ITN70_RS05765 (1173520) 1173520..1173750 + 231 WP_000920568.1 dicB transcriptional regulator DicC -
ITN70_RS05770 (1173734) 1173734..1174012 + 279 Protein_1126 protein YdfX -
ITN70_RS05775 (1174047) 1174047..1174196 + 150 WP_011443592.1 protein YdfW -
ITN70_RS05780 (1174633) 1174633..1174965 - 333 WP_001301033.1 FlxA-like family protein -
ITN70_RS05785 (1175168) 1175168..1175473 - 306 WP_001326990.1 protein YdfV -
ITN70_RS05790 (1175498) 1175498..1175737 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
ITN70_RS05795 (1175737) 1175737..1176024 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
ITN70_RS05800 (1176096) 1176096..1176251 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
ITN70_RS05805 (1176468) 1176468..1176719 + 252 WP_000980994.1 protein Rem -
ITN70_RS05810 (1176786) 1176786..1177064 + 279 WP_012304870.1 hypothetical protein -
ITN70_RS05815 (1177066) 1177066..1178115 + 1050 WP_001265198.1 DUF968 domain-containing protein -
ITN70_RS05820 (1178129) 1178129..1178881 + 753 WP_001047135.1 antitermination protein -
ITN70_RS05825 (1179159) 1179159..1179248 - 90 WP_120795389.1 hypothetical protein -
ITN70_RS05830 (1179303) 1179303..1179515 - 213 WP_000087756.1 cold shock-like protein CspF -
ITN70_RS05835 (1179816) 1179816..1180031 + 216 WP_000066484.1 cold shock-like protein CspB -
ITN70_RS05840 (1180395) 1180395..1180565 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
ITN70_RS05845 (1180785) 1180785..1181000 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1160875..1190368 29493


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T204590 WP_000323025.1 NZ_CP076043:1175737-1176024 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T204590 NZ_CP101123:2822196-2822558 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAACAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAGCAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACATACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGTTCATCAGAAAAATTAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT204590 WP_000534858.1 NZ_CP076043:1175498-1175737 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT204590 NZ_CP101123:2822029-2822199 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References