136091

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2354835..2355361 Replicon chromosome
Accession NZ_CP042843
Organism Escherichia coli strain JME67

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag FVE23_RS11480 Protein ID WP_000323025.1
Coordinates 2354835..2355122 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag FVE23_RS11485 Protein ID WP_000534858.1
Coordinates 2355122..2355361 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FVE23_RS11435 2349859..2350074 - 216 WP_000839590.1 phage lysis protein EssD -
FVE23_RS11440 2350828..2351043 - 216 WP_000066484.1 cold shock-like protein CspB -
FVE23_RS11445 2351344..2351556 + 213 WP_000087756.1 cold shock-like protein CspF -
FVE23_RS11450 2351611..2351700 + 90 WP_120795389.1 hypothetical protein -
FVE23_RS11455 2351978..2352730 - 753 WP_001047135.1 antitermination protein -
FVE23_RS11460 2352744..2353793 - 1050 WP_001393597.1 DUF968 domain-containing protein -
FVE23_RS11465 2353795..2354073 - 279 WP_012304870.1 hypothetical protein -
FVE23_RS11470 2354140..2354391 - 252 WP_000980994.1 hypothetical protein -
FVE23_RS11475 2354608..2354763 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
FVE23_RS11480 2354835..2355122 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
FVE23_RS11485 2355122..2355361 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
FVE23_RS11490 2355386..2355691 + 306 WP_001326990.1 hypothetical protein -
FVE23_RS11495 2355894..2356226 + 333 WP_001301033.1 protein FlxA -
FVE23_RS11500 2356663..2356812 - 150 WP_011443592.1 hypothetical protein -
FVE23_RS11505 2356847..2357125 - 279 Protein_2210 hypothetical protein -
FVE23_RS11510 2357109..2357339 - 231 WP_000920568.1 dicB transcriptional regulator DicC -
FVE23_RS11515 2357423..2357830 + 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
FVE23_RS11520 2357997..2358152 + 156 WP_000379575.1 DUF1391 family protein -
FVE23_RS11525 2358312..2358530 + 219 WP_001171942.1 hypothetical protein -
FVE23_RS11535 2359098..2359286 + 189 WP_000854559.1 cell division inhibition protein DicB -
FVE23_RS11540 2359283..2359474 + 192 WP_001083297.1 lysis protein YdfD -
FVE23_RS11545 2359567..2360334 + 768 Protein_2217 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2340491..2373952 33461


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T136091 WP_000323025.1 NZ_CP042843:c2355122-2354835 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T136091 NZ_CP042843:c2355122-2354835 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT136091 WP_000534858.1 NZ_CP042843:c2355361-2355122 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT136091 NZ_CP042843:c2355361-2355122 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References