197259

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1533875..1534401 Replicon chromosome
Accession NZ_CP072054
Organism Escherichia coli strain K1508

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag J5N95_RS07470 Protein ID WP_000323025.1
Coordinates 1533875..1534162 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag J5N95_RS07475 Protein ID WP_000534858.1
Coordinates 1534162..1534401 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5N95_RS07425 (1528899) 1528899..1529114 - 216 WP_000839590.1 phage lysis protein EssD -
J5N95_RS21810 (1529334) 1529334..1529504 + 171 WP_211180497.1 putative zinc-binding protein YnfU -
J5N95_RS07430 (1529868) 1529868..1530083 - 216 WP_000066484.1 cold shock-like protein CspB -
J5N95_RS07435 (1530384) 1530384..1530596 + 213 WP_000087756.1 cold shock-like protein CspF -
J5N95_RS07440 (1530651) 1530651..1530740 + 90 WP_120795389.1 hypothetical protein -
J5N95_RS07445 (1531018) 1531018..1531770 - 753 WP_001047135.1 antitermination protein -
J5N95_RS07450 (1531784) 1531784..1532833 - 1050 WP_001265198.1 DUF968 domain-containing protein -
J5N95_RS07455 (1532835) 1532835..1533113 - 279 WP_012304870.1 hypothetical protein -
J5N95_RS07460 (1533180) 1533180..1533431 - 252 WP_000980994.1 protein Rem -
J5N95_RS07465 (1533648) 1533648..1533803 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
J5N95_RS07470 (1533875) 1533875..1534162 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
J5N95_RS07475 (1534162) 1534162..1534401 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
J5N95_RS07480 (1534426) 1534426..1534731 + 306 WP_001326990.1 protein YdfV -
J5N95_RS07485 (1534934) 1534934..1535266 + 333 WP_001301033.1 FlxA-like family protein -
J5N95_RS07490 (1535703) 1535703..1535852 - 150 WP_011443592.1 protein YdfW -
J5N95_RS07495 (1535887) 1535887..1536165 - 279 Protein_1477 protein YdfX -
J5N95_RS07500 (1536149) 1536149..1536379 - 231 WP_000920568.1 dicB transcriptional regulator DicC -
J5N95_RS07505 (1536463) 1536463..1536870 + 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
J5N95_RS07510 (1537037) 1537037..1537192 + 156 WP_000379575.1 DUF1391 family protein -
J5N95_RS22040 (1537194) 1537194..1537322 + 129 WP_000344964.1 protein YdfB -
J5N95_RS07515 (1537352) 1537352..1537570 + 219 WP_001171942.1 protein YdfC -
J5N95_RS07520 (1538138) 1538138..1538326 + 189 WP_000854559.1 cell division inhibition protein DicB -
J5N95_RS07525 (1538323) 1538323..1538514 + 192 WP_001083297.1 lysis protein YdfD -
J5N95_RS07530 (1538607) 1538607..1539374 + 768 Protein_1485 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1519531..1552992 33461


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T197259 WP_000323025.1 NZ_CP072054:c1534162-1533875 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T197259 NZ_CP095856:540930-541106 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT197259 WP_000534858.1 NZ_CP072054:c1534401-1534162 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT197259 NZ_CP095856:541152-541568 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References