262745

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1732995..1733521 Replicon chromosome
Accession NZ_CP110018
Organism Escherichia coli strain DH10B

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag OLR78_RS08615 Protein ID WP_000323025.1
Coordinates 1732995..1733282 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag OLR78_RS08620 Protein ID WP_000534858.1
Coordinates 1733282..1733521 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLR78_RS08565 (1728019) 1728019..1728234 - 216 WP_000839590.1 phage lysis protein EssD -
OLR78_RS08570 (1728454) 1728454..1728624 + 171 WP_211180497.1 putative zinc-binding protein YnfU -
OLR78_RS08575 (1728988) 1728988..1729203 - 216 WP_000066484.1 cold shock-like protein CspB -
OLR78_RS08580 (1729504) 1729504..1729716 + 213 WP_000087756.1 cold shock-like protein CspF -
OLR78_RS08585 (1729771) 1729771..1729860 + 90 WP_120795389.1 hypothetical protein -
OLR78_RS08590 (1730138) 1730138..1730890 - 753 WP_001047135.1 antitermination protein -
OLR78_RS08595 (1730904) 1730904..1731953 - 1050 WP_001265198.1 DUF968 domain-containing protein -
OLR78_RS08600 (1731955) 1731955..1732233 - 279 WP_012304870.1 hypothetical protein -
OLR78_RS08605 (1732300) 1732300..1732551 - 252 WP_000980994.1 protein Rem -
OLR78_RS08610 (1732768) 1732768..1732923 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
OLR78_RS08615 (1732995) 1732995..1733282 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
OLR78_RS08620 (1733282) 1733282..1733521 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
OLR78_RS08625 (1733546) 1733546..1733851 + 306 WP_001326990.1 protein YdfV -
OLR78_RS08630 (1734054) 1734054..1734386 + 333 WP_001301033.1 FlxA-like family protein -
OLR78_RS08635 (1734823) 1734823..1734972 - 150 WP_011443592.1 protein YdfW -
OLR78_RS08640 (1735007) 1735007..1735285 - 279 Protein_1690 protein YdfX -
OLR78_RS08645 (1735269) 1735269..1735499 - 231 WP_000920568.1 dicB transcriptional regulator DicC -
OLR78_RS08650 (1735583) 1735583..1735990 + 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
OLR78_RS08655 (1736157) 1736157..1736312 + 156 WP_000379575.1 DUF1391 family protein -
OLR78_RS08660 (1736314) 1736314..1736442 + 129 WP_000344964.1 protein YdfB -
OLR78_RS08665 (1736472) 1736472..1736690 + 219 WP_001171942.1 protein YdfC -
OLR78_RS08670 (1737258) 1737258..1737446 + 189 WP_000854559.1 cell division inhibition protein DicB -
OLR78_RS08675 (1737443) 1737443..1737634 + 192 WP_001083297.1 lysis protein YdfD -
OLR78_RS08680 (1737727) 1737727..1738494 + 768 Protein_1698 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1718651..1753448 34797


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T262745 WP_000323025.1 NZ_CP110018:c1733282-1732995 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT262745 WP_000534858.1 NZ_CP110018:c1733521-1733282 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References