126352

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1634263..1634789 Replicon chromosome
Accession NZ_CP040663
Organism Escherichia coli strain EK2009

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag FE383_RS08050 Protein ID WP_000323025.1
Coordinates 1634263..1634550 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag FE383_RS08055 Protein ID WP_000534858.1
Coordinates 1634550..1634789 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FE383_RS08005 1629287..1629502 - 216 WP_000839590.1 phage lysis protein EssD -
FE383_RS22480 1629722..1629892 + 171 WP_211180497.1 putative zinc-binding protein YnfU -
FE383_RS08010 1630256..1630471 - 216 WP_000066484.1 cold shock-like protein CspB -
FE383_RS08015 1630772..1630984 + 213 WP_000087756.1 cold shock-like protein CspF -
FE383_RS08020 1631039..1631128 + 90 WP_120795389.1 hypothetical protein -
FE383_RS08025 1631406..1632158 - 753 WP_001047135.1 antitermination protein -
FE383_RS08030 1632172..1633221 - 1050 WP_001265198.1 DUF968 domain-containing protein -
FE383_RS08035 1633223..1633501 - 279 WP_012304870.1 hypothetical protein -
FE383_RS08040 1633568..1633819 - 252 WP_000980994.1 hypothetical protein -
FE383_RS08045 1634036..1634191 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
FE383_RS08050 1634263..1634550 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
FE383_RS08055 1634550..1634789 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
FE383_RS08060 1634814..1635119 + 306 WP_001326990.1 hypothetical protein -
FE383_RS08065 1635322..1635654 + 333 WP_001301033.1 protein FlxA -
FE383_RS08070 1636091..1636240 - 150 WP_011443592.1 hypothetical protein -
FE383_RS08075 1636275..1636553 - 279 Protein_1572 hypothetical protein -
FE383_RS08080 1636537..1636767 - 231 WP_000920568.1 dicB transcriptional regulator DicC -
FE383_RS08085 1636851..1637258 + 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
FE383_RS08090 1637425..1637580 + 156 WP_000379575.1 DUF1391 family protein -
FE383_RS08095 1637740..1637958 + 219 WP_001171942.1 hypothetical protein -
FE383_RS08105 1638526..1638714 + 189 WP_000854559.1 cell division inhibition protein DicB -
FE383_RS08110 1638711..1638902 + 192 WP_001083297.1 lysis protein YdfD -
FE383_RS08115 1638995..1639762 + 768 Protein_1579 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1619919..1653380 33461


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T126352 WP_000323025.1 NZ_CP040663:c1634550-1634263 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T126352 NZ_CP040663:c1634550-1634263 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT126352 WP_000534858.1 NZ_CP040663:c1634789-1634550 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT126352 NZ_CP040663:c1634789-1634550 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References