289589

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2223478..2224004 Replicon chromosome
Accession NZ_LR882052
Organism Escherichia coli isolate 2015-01-466

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag QREC_RS10675 Protein ID WP_000323025.1
Coordinates 2223717..2224004 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag QREC_RS10670 Protein ID WP_000534858.1
Coordinates 2223478..2223717 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QREC_RS10635 2218675..2218905 + 231 WP_000920568.1 dicB transcriptional regulator DicC -
QREC_RS10640 2218801..2219184 - 384 WP_191514957.1 IS66 family insertion sequence element accessory protein TnpB -
QREC_RS10645 2219181..2219585 - 405 WP_000839179.1 IS66 family insertion sequence hypothetical protein -
QREC_RS10650 2219807..2220094 + 288 Protein_2078 hypothetical protein -
QREC_RS10655 2220863..2222176 + 1314 WP_000589005.1 ISNCY family transposase -
QREC_RS10660 2222613..2222945 - 333 WP_001301033.1 protein FlxA -
QREC_RS10665 2223148..2223453 - 306 WP_001326990.1 hypothetical protein -
QREC_RS10670 2223478..2223717 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
QREC_RS10675 2223717..2224004 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
QREC_RS10680 2224076..2224231 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
QREC_RS10685 2224448..2224699 + 252 WP_000980994.1 hypothetical protein -
QREC_RS10690 2224766..2225044 + 279 WP_012304870.1 hypothetical protein -
QREC_RS10695 2225046..2226095 + 1050 WP_001265199.1 DUF968 domain-containing protein -
QREC_RS10700 2226109..2226861 + 753 WP_001047135.1 antitermination protein -
QREC_RS10705 2227139..2227228 - 90 WP_120795389.1 hypothetical protein -
QREC_RS10710 2227283..2227495 - 213 WP_000087756.1 cold shock-like protein CspF -
QREC_RS10715 2227796..2228011 + 216 WP_000066484.1 cold shock-like protein CspB -
QREC_RS10720 2228765..2228980 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2200582..2239192 38610
- flank IS/Tn - - 2219181..2219585 404


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T289589 WP_000323025.1 NZ_LR882052:2223717-2224004 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT289589 WP_000534858.1 NZ_LR882052:2223478-2223717 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References