Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2223478..2224004 Replicon chromosome
Accession NZ_LR882052
Organism Escherichia coli isolate 2015-01-466

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag QREC_RS10675 Protein ID WP_000323025.1
Coordinates 2223717..2224004 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag QREC_RS10670 Protein ID WP_000534858.1
Coordinates 2223478..2223717 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QREC_RS10635 2218675..2218905 + 231 WP_000920568.1 dicB transcriptional regulator DicC -
QREC_RS10640 2218801..2219184 - 384 WP_191514957.1 IS66 family insertion sequence element accessory protein TnpB -
QREC_RS10645 2219181..2219585 - 405 WP_000839179.1 IS66 family insertion sequence hypothetical protein -
QREC_RS10650 2219807..2220094 + 288 Protein_2078 hypothetical protein -
QREC_RS10655 2220863..2222176 + 1314 WP_000589005.1 ISNCY family transposase -
QREC_RS10660 2222613..2222945 - 333 WP_001301033.1 protein FlxA -
QREC_RS10665 2223148..2223453 - 306 WP_001326990.1 hypothetical protein -
QREC_RS10670 2223478..2223717 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
QREC_RS10675 2223717..2224004 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
QREC_RS10680 2224076..2224231 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
QREC_RS10685 2224448..2224699 + 252 WP_000980994.1 hypothetical protein -
QREC_RS10690 2224766..2225044 + 279 WP_012304870.1 hypothetical protein -
QREC_RS10695 2225046..2226095 + 1050 WP_001265199.1 DUF968 domain-containing protein -
QREC_RS10700 2226109..2226861 + 753 WP_001047135.1 antitermination protein -
QREC_RS10705 2227139..2227228 - 90 WP_120795389.1 hypothetical protein -
QREC_RS10710 2227283..2227495 - 213 WP_000087756.1 cold shock-like protein CspF -
QREC_RS10715 2227796..2228011 + 216 WP_000066484.1 cold shock-like protein CspB -
QREC_RS10720 2228765..2228980 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2200582..2239192 38610
- flank IS/Tn - - 2219181..2219585 404


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T289589 WP_000323025.1 NZ_LR882052:2223717-2224004 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT289589 WP_000534858.1 NZ_LR882052:2223478-2223717 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References