187058

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2888647..2889173 Replicon chromosome
Accession NZ_CP068281
Organism Escherichia coli strain CY706

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag JJW04_RS14095 Protein ID WP_000323025.1
Coordinates 2888647..2888934 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag JJW04_RS14100 Protein ID WP_000534858.1
Coordinates 2888934..2889173 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJW04_RS14045 (2883671) 2883671..2883886 - 216 WP_000839590.1 phage lysis protein EssD -
JJW04_RS14050 (2884106) 2884106..2884276 + 171 WP_211180497.1 putative zinc-binding protein YnfU -
JJW04_RS14055 (2884640) 2884640..2884855 - 216 WP_000066484.1 cold shock-like protein CspB -
JJW04_RS14060 (2885156) 2885156..2885368 + 213 WP_000087756.1 cold shock-like protein CspF -
JJW04_RS14065 (2885423) 2885423..2885512 + 90 WP_120795389.1 hypothetical protein -
JJW04_RS14070 (2885790) 2885790..2886542 - 753 WP_001047135.1 antitermination protein -
JJW04_RS14075 (2886556) 2886556..2887605 - 1050 WP_001265198.1 DUF968 domain-containing protein -
JJW04_RS14080 (2887607) 2887607..2887885 - 279 WP_012304870.1 hypothetical protein -
JJW04_RS14085 (2887952) 2887952..2888203 - 252 WP_000980994.1 protein Rem -
JJW04_RS14090 (2888420) 2888420..2888575 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
JJW04_RS14095 (2888647) 2888647..2888934 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
JJW04_RS14100 (2888934) 2888934..2889173 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
JJW04_RS14105 (2889198) 2889198..2889503 + 306 WP_001326990.1 protein YdfV -
JJW04_RS14110 (2889706) 2889706..2890038 + 333 WP_001301033.1 FlxA-like family protein -
JJW04_RS14115 (2890475) 2890475..2890624 - 150 WP_011443592.1 protein YdfW -
JJW04_RS14120 (2890659) 2890659..2890937 - 279 Protein_2759 hypothetical protein -
JJW04_RS14125 (2890921) 2890921..2891151 - 231 WP_000920568.1 dicB transcriptional regulator DicC -
JJW04_RS14130 (2891235) 2891235..2891642 + 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
JJW04_RS14135 (2891809) 2891809..2891964 + 156 WP_000379575.1 DUF1391 family protein -
JJW04_RS23240 (2891966) 2891966..2892094 + 129 WP_000344964.1 protein YdfB -
JJW04_RS14140 (2892124) 2892124..2892342 + 219 WP_001171942.1 protein YdfC -
JJW04_RS14145 (2892910) 2892910..2893098 + 189 WP_000854559.1 cell division inhibition protein DicB -
JJW04_RS14150 (2893095) 2893095..2893286 + 192 WP_001083297.1 lysis protein YdfD -
JJW04_RS14155 (2893379) 2893379..2894146 + 768 Protein_2767 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2874303..2909100 34797


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T187058 WP_000323025.1 NZ_CP068281:c2888934-2888647 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T187058 NZ_CP089777:721288-721683 [Mycobacterium tuberculosis]
ATGGTGATCGACACGTCCGCGCTCGTTGCGATGCTCAGCGACGAGCCAGACGCAGAGCGGTTCGAGGCCGCCGTCGAAGC
CGACCACATCCGGCTGATGTCGACGGCGTCTTACCTGGAAACGGCACTCGTGATAGAAGCCCGCTTCGGTGAACCGGGCG
GACGTGAGCTGGATCTGTGGCTTCATCGCGCCGCGGTCGACCTTGTTGCCGTGCATGCCGACCAAGCGGATGCCGCGCGC
GCCGCCTACCGCACGTACGGCAAGGGAAGGCATCGTGCGGGGCTCAACTACGGCGACTGCTTCTCATACGGCCTCGCCAA
GATCAGCGGCCAGCCACTCCTGTTCAAGGGCGAAGATTTCCAACACACCGACATCGCCACGGTCGCGCTGCCCTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT187058 WP_000534858.1 NZ_CP068281:c2889173-2888934 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT187058 NZ_CP089777:721034-721288 [Mycobacterium tuberculosis]
ATGGCGCTGAGTATCAAGCACCCGGAAGCCGACCGGCTCGCGCGAGCGCTTGCGGCGCGCACCGGCGAGACGTTGACCGA
GGCAGTGGTTACCGCGTTGCGCGAGCGGCTCGCTCGTGAGACTGGGCGTGCCCGTGTTGTCCCGTTGCGCGACGAGCTTG
CCGCGATTCGGCACCGGTGCGCAGCGTTGCCGGTGGTCGACAACCGGTCCGCTGAGGCGATTCTCGGCTATGACGAGCGC
GGATTGCCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References