181513

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1639601..1640127 Replicon chromosome
Accession NZ_CP064680
Organism Escherichia coli K-12 strain CETR1G40

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag IVL01_RS08030 Protein ID WP_000323025.1
Coordinates 1639601..1639888 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag IVL01_RS08035 Protein ID WP_000534858.1
Coordinates 1639888..1640127 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IVL01_RS07985 1634625..1634840 - 216 WP_000839590.1 phage lysis protein EssD -
IVL01_RS07990 1635594..1635809 - 216 WP_000066484.1 cold shock-like protein CspB -
IVL01_RS07995 1636110..1636322 + 213 WP_000087756.1 cold shock-like protein CspF -
IVL01_RS08000 1636377..1636466 + 90 WP_120795389.1 hypothetical protein -
IVL01_RS08005 1636744..1637496 - 753 WP_001047135.1 antitermination protein -
IVL01_RS08010 1637510..1638559 - 1050 WP_001393597.1 DUF968 domain-containing protein -
IVL01_RS08015 1638561..1638839 - 279 WP_012304870.1 hypothetical protein -
IVL01_RS08020 1638906..1639157 - 252 WP_000980994.1 hypothetical protein -
IVL01_RS08025 1639374..1639529 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
IVL01_RS08030 1639601..1639888 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
IVL01_RS08035 1639888..1640127 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
IVL01_RS08040 1640152..1640457 + 306 WP_001326990.1 hypothetical protein -
IVL01_RS08045 1640660..1640992 + 333 WP_001301033.1 protein FlxA -
IVL01_RS08050 1641429..1641578 - 150 WP_011443592.1 hypothetical protein -
IVL01_RS08055 1641613..1641891 - 279 Protein_1574 hypothetical protein -
IVL01_RS08060 1641875..1642105 - 231 WP_000920568.1 dicB transcriptional regulator DicC -
IVL01_RS08065 1642189..1642596 + 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
IVL01_RS08070 1642763..1642918 + 156 WP_000379575.1 DUF1391 family protein -
IVL01_RS08075 1643078..1643296 + 219 WP_001171942.1 hypothetical protein -
IVL01_RS08080 1643864..1644052 + 189 WP_000854559.1 cell division inhibition protein DicB -
IVL01_RS08085 1644049..1644240 + 192 WP_001083297.1 lysis protein YdfD -
IVL01_RS08090 1644333..1645100 + 768 Protein_1581 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1625257..1658718 33461


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T181513 WP_000323025.1 NZ_CP064680:c1639888-1639601 [Escherichia coli K-12]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T181513 NZ_CP085906:326424-326765 [Enterococcus faecium]
GTGTCAGAAGAAAGAATTTATATTCCTAAAAAAGGTGATATTGTGTGGATTGATTTTGATCCTTCGATAGGAAAAGAAAT
TCAAAAAAGACGACCAGGACTAGTCGTCTCTCGTTATGAGTTTAATCGTAAAACAATGTTTTCGGTCATATGTCCGATTA
CTTCCACGATAAAGAATTTACCGACACGTTACTCATTACCAGAAGAGCTAGATATAAAAGGACAAGTACTTATTTCTCAA
TTAAAATCACTTGATTTTAAGGAACGAAGACTCAAAAAAATAGAAAACCTGCCATTGCAAGACATGGCTAAAATTGATCA
GATTATACAATATATGTTTTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT181513 WP_000534858.1 NZ_CP064680:c1640127-1639888 [Escherichia coli K-12]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT181513 NZ_CP085906:326194-326424 [Enterococcus faecium]
ATGCTTGTTACAAAATCTAGATTACAAGGAAGTTCTGTAGTGGTTACTTTACCTTCTGATAACGGAAAGAAACCTTCAGA
AAACCAAGAATATATCGTTGTATATTCTGACGATGGGACAATTACGTTAGTTCCAAAAATTGAAGATCCATTTAGTGGTG
GAGAAGAGGCCGAATATTATGAAAAAGACGAATGGGAAGATTTAACTCCTGAAGGGAGAGAAAGGTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References