Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1779310..1779836 Replicon chromosome
Accession NZ_CP040643
Organism Escherichia coli strain BE104

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag FGC38_RS08915 Protein ID WP_000323025.1
Coordinates 1779310..1779597 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag FGC38_RS08920 Protein ID WP_000534858.1
Coordinates 1779597..1779836 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGC38_RS08870 1774334..1774549 - 216 WP_000839590.1 phage lysis protein EssD -
FGC38_RS23520 1774769..1774939 + 171 WP_211180497.1 putative zinc-binding protein YnfU -
FGC38_RS08875 1775303..1775518 - 216 WP_000066484.1 cold shock-like protein CspB -
FGC38_RS08880 1775819..1776031 + 213 WP_000087756.1 cold shock-like protein CspF -
FGC38_RS08885 1776086..1776175 + 90 WP_120795389.1 hypothetical protein -
FGC38_RS08890 1776453..1777205 - 753 WP_001047135.1 antitermination protein -
FGC38_RS08895 1777219..1778268 - 1050 WP_001265198.1 DUF968 domain-containing protein -
FGC38_RS08900 1778270..1778548 - 279 WP_012304870.1 hypothetical protein -
FGC38_RS08905 1778615..1778866 - 252 WP_000980994.1 hypothetical protein -
FGC38_RS08910 1779083..1779238 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
FGC38_RS08915 1779310..1779597 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
FGC38_RS08920 1779597..1779836 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
FGC38_RS08925 1779861..1780166 + 306 WP_001326990.1 hypothetical protein -
FGC38_RS08930 1780369..1780701 + 333 WP_001301033.1 protein FlxA -
FGC38_RS08935 1781138..1781287 - 150 WP_011443592.1 hypothetical protein -
FGC38_RS08940 1781322..1781600 - 279 Protein_1734 hypothetical protein -
FGC38_RS08945 1781584..1781814 - 231 WP_000920568.1 dicB transcriptional regulator DicC -
FGC38_RS08950 1781898..1782305 + 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
FGC38_RS08955 1782472..1782627 + 156 WP_000379575.1 DUF1391 family protein -
FGC38_RS08960 1782787..1783005 + 219 WP_001171942.1 hypothetical protein -
FGC38_RS08970 1783573..1783761 + 189 WP_000854559.1 cell division inhibition protein DicB -
FGC38_RS08975 1783758..1783949 + 192 WP_001083297.1 lysis protein YdfD -
FGC38_RS08980 1784042..1784809 + 768 Protein_1741 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1764966..1798427 33461


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T126265 WP_000323025.1 NZ_CP040643:c1779597-1779310 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T126265 NZ_CP040643:c1779597-1779310 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT126265 WP_000534858.1 NZ_CP040643:c1779836-1779597 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT126265 NZ_CP040643:c1779836-1779597 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References