126265

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1779310..1779836 Replicon chromosome
Accession NZ_CP040643
Organism Escherichia coli strain BE104

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag FGC38_RS08915 Protein ID WP_000323025.1
Coordinates 1779310..1779597 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag FGC38_RS08920 Protein ID WP_000534858.1
Coordinates 1779597..1779836 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGC38_RS08870 1774334..1774549 - 216 WP_000839590.1 phage lysis protein EssD -
FGC38_RS23520 1774769..1774939 + 171 WP_211180497.1 putative zinc-binding protein YnfU -
FGC38_RS08875 1775303..1775518 - 216 WP_000066484.1 cold shock-like protein CspB -
FGC38_RS08880 1775819..1776031 + 213 WP_000087756.1 cold shock-like protein CspF -
FGC38_RS08885 1776086..1776175 + 90 WP_120795389.1 hypothetical protein -
FGC38_RS08890 1776453..1777205 - 753 WP_001047135.1 antitermination protein -
FGC38_RS08895 1777219..1778268 - 1050 WP_001265198.1 DUF968 domain-containing protein -
FGC38_RS08900 1778270..1778548 - 279 WP_012304870.1 hypothetical protein -
FGC38_RS08905 1778615..1778866 - 252 WP_000980994.1 hypothetical protein -
FGC38_RS08910 1779083..1779238 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
FGC38_RS08915 1779310..1779597 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
FGC38_RS08920 1779597..1779836 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
FGC38_RS08925 1779861..1780166 + 306 WP_001326990.1 hypothetical protein -
FGC38_RS08930 1780369..1780701 + 333 WP_001301033.1 protein FlxA -
FGC38_RS08935 1781138..1781287 - 150 WP_011443592.1 hypothetical protein -
FGC38_RS08940 1781322..1781600 - 279 Protein_1734 hypothetical protein -
FGC38_RS08945 1781584..1781814 - 231 WP_000920568.1 dicB transcriptional regulator DicC -
FGC38_RS08950 1781898..1782305 + 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
FGC38_RS08955 1782472..1782627 + 156 WP_000379575.1 DUF1391 family protein -
FGC38_RS08960 1782787..1783005 + 219 WP_001171942.1 hypothetical protein -
FGC38_RS08970 1783573..1783761 + 189 WP_000854559.1 cell division inhibition protein DicB -
FGC38_RS08975 1783758..1783949 + 192 WP_001083297.1 lysis protein YdfD -
FGC38_RS08980 1784042..1784809 + 768 Protein_1741 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1764966..1798427 33461


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T126265 WP_000323025.1 NZ_CP040643:c1779597-1779310 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T126265 NZ_CP040643:c1779597-1779310 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT126265 WP_000534858.1 NZ_CP040643:c1779836-1779597 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT126265 NZ_CP040643:c1779836-1779597 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References