253575

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1519123..1519649 Replicon chromosome
Accession NZ_CP102380
Organism Escherichia coli strain BM28

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag NR349_RS07420 Protein ID WP_000323025.1
Coordinates 1519123..1519410 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag NR349_RS07425 Protein ID WP_000534858.1
Coordinates 1519410..1519649 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NR349_RS07370 (1514147) 1514147..1514362 - 216 WP_000839590.1 phage lysis protein EssD -
NR349_RS07375 (1514582) 1514582..1514752 + 171 WP_211180497.1 putative zinc-binding protein YnfU -
NR349_RS07380 (1515116) 1515116..1515331 - 216 WP_000066484.1 cold shock-like protein CspB -
NR349_RS07385 (1515632) 1515632..1515844 + 213 WP_000087756.1 cold shock-like protein CspF -
NR349_RS07390 (1515899) 1515899..1515988 + 90 WP_120795389.1 hypothetical protein -
NR349_RS07395 (1516266) 1516266..1517018 - 753 WP_001047135.1 antitermination protein -
NR349_RS07400 (1517032) 1517032..1518081 - 1050 WP_001393597.1 DUF968 domain-containing protein -
NR349_RS07405 (1518083) 1518083..1518361 - 279 WP_012304870.1 hypothetical protein -
NR349_RS07410 (1518428) 1518428..1518679 - 252 WP_000980994.1 protein Rem -
NR349_RS07415 (1518896) 1518896..1519051 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
NR349_RS07420 (1519123) 1519123..1519410 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
NR349_RS07425 (1519410) 1519410..1519649 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
NR349_RS07430 (1519674) 1519674..1519979 + 306 WP_001326990.1 protein YdfV -
NR349_RS07435 (1520182) 1520182..1520514 + 333 WP_001301033.1 FlxA-like family protein -
NR349_RS07440 (1520951) 1520951..1521100 - 150 WP_011443592.1 protein YdfW -
NR349_RS07445 (1521135) 1521135..1521413 - 279 Protein_1453 hypothetical protein -
NR349_RS07450 (1521397) 1521397..1521627 - 231 WP_000920568.1 dicB transcriptional regulator DicC -
NR349_RS07455 (1521711) 1521711..1522118 + 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
NR349_RS07460 (1522285) 1522285..1522440 + 156 WP_000379575.1 DUF1391 family protein -
NR349_RS07465 (1522442) 1522442..1522570 + 129 WP_000344964.1 protein YdfB -
NR349_RS07470 (1522600) 1522600..1522818 + 219 WP_001171942.1 protein YdfC -
NR349_RS07475 (1523386) 1523386..1523574 + 189 WP_000854559.1 cell division inhibition protein DicB -
NR349_RS07480 (1523571) 1523571..1523762 + 192 WP_001083297.1 lysis protein YdfD -
NR349_RS07485 (1523855) 1523855..1524622 + 768 Protein_1461 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1503513..1538240 34727


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T253575 WP_000323025.1 NZ_CP102380:c1519410-1519123 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT253575 WP_000534858.1 NZ_CP102380:c1519649-1519410 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References