55926

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1624916..1625442 Replicon chromosome
Accession NZ_CP012127
Organism Escherichia coli strain DH1Ec169

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag ADZ28_RS08045 Protein ID WP_000323025.1
Coordinates 1624916..1625203 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag ADZ28_RS08050 Protein ID WP_000534858.1
Coordinates 1625203..1625442 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ADZ28_RS08005 1619940..1620155 - 216 WP_000839590.1 phage lysis protein EssD -
ADZ28_RS08010 1620909..1621124 - 216 WP_000066484.1 cold shock-like protein CspB -
ADZ28_RS08015 1621425..1621637 + 213 WP_000087756.1 cold shock-like protein CspF -
ADZ28_RS25355 1621692..1621781 + 90 WP_120795389.1 hypothetical protein -
ADZ28_RS08020 1622059..1622811 - 753 WP_001047135.1 antitermination protein -
ADZ28_RS08025 1622825..1623874 - 1050 WP_001265198.1 DUF968 domain-containing protein -
ADZ28_RS08030 1623876..1624154 - 279 WP_012304870.1 hypothetical protein -
ADZ28_RS08035 1624221..1624472 - 252 WP_000980994.1 hypothetical protein -
ADZ28_RS08040 1624689..1624844 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
ADZ28_RS08045 1624916..1625203 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
ADZ28_RS08050 1625203..1625442 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
ADZ28_RS23550 1625467..1625772 + 306 WP_001326990.1 hypothetical protein -
ADZ28_RS08055 1625975..1626307 + 333 WP_001301033.1 protein FlxA -
ADZ28_RS22785 1626744..1626893 - 150 WP_011443592.1 hypothetical protein -
ADZ28_RS08060 1626928..1627206 - 279 Protein_1547 hypothetical protein -
ADZ28_RS08065 1627190..1627420 - 231 WP_000920568.1 dicB transcriptional regulator DicC -
ADZ28_RS08070 1627504..1627911 + 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
ADZ28_RS08075 1628078..1628233 + 156 WP_000379575.1 DUF1391 family protein -
ADZ28_RS08080 1628393..1628611 + 219 WP_001171942.1 hypothetical protein -
ADZ28_RS08090 1629179..1629367 + 189 WP_000854559.1 cell division inhibition protein DicB -
ADZ28_RS08095 1629364..1629555 + 192 WP_001083297.1 lysis protein YdfD -
ADZ28_RS23565 1629648..1630415 + 768 Protein_1554 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1610572..1644033 33461


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T55926 WP_000323025.1 NZ_CP012127:c1625203-1624916 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T55926 NZ_CP012127:c1625203-1624916 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT55926 WP_000534858.1 NZ_CP012127:c1625442-1625203 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT55926 NZ_CP012127:c1625442-1625203 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References