Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1594243..1594769 Replicon chromosome
Accession NZ_LM995446
Organism Escherichia coli strain K-12 substr. RV308

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag ECRV308_RS07955 Protein ID WP_000323025.1
Coordinates 1594243..1594530 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag ECRV308_RS07960 Protein ID WP_000534858.1
Coordinates 1594530..1594769 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECRV308_RS07915 1589267..1589482 - 216 WP_000839590.1 phage lysis protein EssD -
ECRV308_RS07920 1590236..1590451 - 216 WP_000066484.1 cold shock-like protein CspB -
ECRV308_RS07925 1590752..1590964 + 213 WP_000087756.1 cold shock-like protein CspF -
ECRV308_RS25340 1591019..1591108 + 90 WP_120795389.1 hypothetical protein -
ECRV308_RS07930 1591386..1592138 - 753 WP_001047135.1 antitermination protein -
ECRV308_RS07935 1592152..1593201 - 1050 WP_001265198.1 DUF968 domain-containing protein -
ECRV308_RS07940 1593203..1593481 - 279 WP_012304870.1 hypothetical protein -
ECRV308_RS07945 1593548..1593799 - 252 WP_000980994.1 hypothetical protein -
ECRV308_RS07950 1594016..1594171 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
ECRV308_RS07955 1594243..1594530 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
ECRV308_RS07960 1594530..1594769 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
ECRV308_RS23530 1594794..1595099 + 306 WP_001326990.1 hypothetical protein -
ECRV308_RS07965 1595302..1595634 + 333 WP_001301033.1 protein FlxA -
ECRV308_RS22835 1596071..1596220 - 150 WP_011443592.1 hypothetical protein -
ECRV308_RS07970 1596255..1596533 - 279 Protein_1521 hypothetical protein -
ECRV308_RS07975 1596517..1596747 - 231 WP_000920568.1 dicB transcriptional regulator DicC -
ECRV308_RS07980 1596831..1597238 + 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
ECRV308_RS07985 1597405..1597560 + 156 WP_000379575.1 DUF1391 family protein -
ECRV308_RS07990 1597720..1597938 + 219 WP_001171942.1 hypothetical protein -
ECRV308_RS08000 1598506..1598694 + 189 WP_000854559.1 cell division inhibition protein DicB -
ECRV308_RS08005 1598691..1598882 + 192 WP_001083297.1 lysis protein YdfD -
ECRV308_RS23545 1598975..1599742 + 768 Protein_1528 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1579899..1613360 33461


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T285435 WP_000323025.1 NZ_LM995446:c1594530-1594243 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT285435 WP_000534858.1 NZ_LM995446:c1594769-1594530 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References