108583

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2276645..2277171 Replicon chromosome
Accession NZ_CP031214
Organism Escherichia coli strain C600

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag DK885_RS11725 Protein ID WP_000323025.1
Coordinates 2276884..2277171 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag DK885_RS11720 Protein ID WP_000534858.1
Coordinates 2276645..2276884 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DK885_RS11655 2271672..2272439 - 768 Protein_2135 exonuclease -
DK885_RS11660 2272532..2272723 - 192 WP_001083297.1 lysis protein YdfD -
DK885_RS11665 2272720..2272908 - 189 WP_000854559.1 cell division inhibition protein DicB -
DK885_RS11675 2273476..2273694 - 219 WP_001171942.1 hypothetical protein -
DK885_RS11685 2273854..2274009 - 156 WP_000379575.1 DUF1391 family protein -
DK885_RS11690 2274176..2274583 - 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
DK885_RS11695 2274667..2274897 + 231 WP_000920568.1 dicB transcriptional regulator DicC -
DK885_RS11700 2274881..2275159 + 279 Protein_2142 hypothetical protein -
DK885_RS23905 2275194..2275343 + 150 WP_011443592.1 hypothetical protein -
DK885_RS11710 2275780..2276112 - 333 WP_001301033.1 protein FlxA -
DK885_RS11715 2276315..2276620 - 306 WP_001326990.1 hypothetical protein -
DK885_RS11720 2276645..2276884 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
DK885_RS11725 2276884..2277171 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
DK885_RS11730 2277243..2277398 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
DK885_RS11735 2277615..2277866 + 252 WP_000980994.1 hypothetical protein -
DK885_RS11740 2277933..2278211 + 279 WP_012304870.1 hypothetical protein -
DK885_RS11745 2278213..2279262 + 1050 WP_001265198.1 DUF968 domain-containing protein -
DK885_RS11750 2279276..2280028 + 753 WP_001047135.1 antitermination protein -
DK885_RS23910 2280306..2280395 - 90 WP_120795389.1 hypothetical protein -
DK885_RS11755 2280450..2280662 - 213 WP_000087756.1 cold shock-like protein CspF -
DK885_RS11760 2280963..2281178 + 216 WP_000066484.1 cold shock-like protein CspB -
DK885_RS24245 2281542..2281712 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
DK885_RS11765 2281932..2282147 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2258054..2298412 40358


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T108583 WP_000323025.1 NZ_CP031214:2276884-2277171 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T108583 NZ_CP031214:2276884-2277171 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT108583 WP_000534858.1 NZ_CP031214:2276645-2276884 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT108583 NZ_CP031214:2276645-2276884 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References