75071

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2273385..2273911 Replicon chromosome
Accession NZ_CP020543
Organism Escherichia coli C

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag B6N50_RS11620 Protein ID WP_047402633.1
Coordinates 2273624..2273911 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag B6N50_RS11615 Protein ID WP_000534858.1
Coordinates 2273385..2273624 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B6N50_RS23910 2268489..2268776 + 288 Protein_2115 hypothetical protein -
B6N50_RS11600 (B6N50_11600) 2270770..2272083 + 1314 WP_000589005.1 ISNCY family transposase -
B6N50_RS11605 (B6N50_11605) 2272520..2272852 - 333 WP_001301033.1 protein FlxA -
B6N50_RS11610 (B6N50_11610) 2273055..2273360 - 306 WP_001326990.1 hypothetical protein -
B6N50_RS11615 (B6N50_11615) 2273385..2273624 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
B6N50_RS11620 (B6N50_11620) 2273624..2273911 + 288 WP_047402633.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
B6N50_RS11625 (B6N50_11625) 2273983..2274138 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
B6N50_RS11630 (B6N50_11630) 2274355..2274606 + 252 WP_000980994.1 hypothetical protein -
B6N50_RS11635 (B6N50_11635) 2274673..2274951 + 279 WP_012304870.1 hypothetical protein -
B6N50_RS11640 (B6N50_11640) 2274953..2276002 + 1050 WP_001265199.1 DUF968 domain-containing protein -
B6N50_RS11645 (B6N50_11645) 2276016..2276768 + 753 WP_001047135.1 antitermination protein -
B6N50_RS23655 2277046..2277135 - 90 WP_120795389.1 hypothetical protein -
B6N50_RS11650 (B6N50_11650) 2277190..2277402 - 213 WP_000087756.1 cold shock-like protein CspF -
B6N50_RS11655 (B6N50_11655) 2277703..2277918 + 216 WP_000066484.1 cold shock-like protein CspB -
B6N50_RS24020 2278282..2278452 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
B6N50_RS11660 (B6N50_11660) 2278672..2278887 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2249542..2301270 51728


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11224.28 Da        Isoelectric Point: 10.4221

>T75071 WP_047402633.1 NZ_CP020543:2273624-2273911 [Escherichia coli C]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLKSPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T75071 NZ_CP020543:2273624-2273911 [Escherichia coli C]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTAAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT75071 WP_000534858.1 NZ_CP020543:2273385-2273624 [Escherichia coli C]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT75071 NZ_CP020543:2273385-2273624 [Escherichia coli C]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References