Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2097975..2098501 | Replicon | chromosome |
| Accession | NZ_CP087110 | ||
| Organism | Escherichia coli strain PJ-T13 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | LM520_RS10205 | Protein ID | WP_000323025.1 |
| Coordinates | 2098214..2098501 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | LM520_RS10200 | Protein ID | WP_000534858.1 |
| Coordinates | 2097975..2098214 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LM520_RS10145 (2093002) | 2093002..2093769 | - | 768 | Protein_1982 | exonuclease | - |
| LM520_RS10150 (2093862) | 2093862..2094053 | - | 192 | WP_001083297.1 | lysis protein YdfD | - |
| LM520_RS10155 (2094050) | 2094050..2094238 | - | 189 | WP_000854559.1 | cell division inhibition protein DicB | - |
| LM520_RS10160 (2094806) | 2094806..2095024 | - | 219 | WP_001171942.1 | protein YdfC | - |
| LM520_RS24150 (2095054) | 2095054..2095182 | - | 129 | WP_000344964.1 | protein YdfB | - |
| LM520_RS10165 (2095184) | 2095184..2095339 | - | 156 | WP_000379575.1 | DUF1391 family protein | - |
| LM520_RS10170 (2095506) | 2095506..2095913 | - | 408 | WP_000448564.1 | DNA-binding transcriptional dual regulator DicA | - |
| LM520_RS10175 (2095997) | 2095997..2096227 | + | 231 | WP_000920568.1 | dicB transcriptional regulator DicC | - |
| LM520_RS10180 (2096211) | 2096211..2096489 | + | 279 | Protein_1990 | hypothetical protein | - |
| LM520_RS10185 (2096524) | 2096524..2096673 | + | 150 | WP_011443592.1 | protein YdfW | - |
| LM520_RS10190 (2097110) | 2097110..2097442 | - | 333 | WP_001301033.1 | FlxA-like family protein | - |
| LM520_RS10195 (2097645) | 2097645..2097950 | - | 306 | WP_001326990.1 | protein YdfV | - |
| LM520_RS10200 (2097975) | 2097975..2098214 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| LM520_RS10205 (2098214) | 2098214..2098501 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| LM520_RS10210 (2098573) | 2098573..2098728 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| LM520_RS10215 (2098945) | 2098945..2099196 | + | 252 | WP_000980994.1 | protein Rem | - |
| LM520_RS10220 (2099263) | 2099263..2099541 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| LM520_RS10225 (2099543) | 2099543..2100592 | + | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| LM520_RS10230 (2100606) | 2100606..2101358 | + | 753 | WP_001047135.1 | antitermination protein | - |
| LM520_RS10235 (2101636) | 2101636..2101725 | - | 90 | WP_120795389.1 | hypothetical protein | - |
| LM520_RS10240 (2101780) | 2101780..2101992 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| LM520_RS10245 (2102293) | 2102293..2102508 | + | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| LM520_RS10250 (2102872) | 2102872..2103042 | - | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| LM520_RS10255 (2103262) | 2103262..2103477 | + | 216 | WP_000839590.1 | phage lysis protein EssD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| inside | Prophage | - | - | 2074255..2130381 | 56126 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T224740 WP_000323025.1 NZ_CP087110:2098214-2098501 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T224740 NZ_CP120399:c4010849-4010565 [Salmonella enterica subsp. enterica serovar Typhi]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTTGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTTGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT224740 WP_000534858.1 NZ_CP087110:2097975-2098214 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT224740 NZ_CP120399:c4011081-4010839 [Salmonella enterica subsp. enterica serovar Typhi]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCACTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCACTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|