136470

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2247464..2247990 Replicon chromosome
Accession NZ_CP042893
Organism Escherichia coli strain CFSAN061772

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag CA901_RS10850 Protein ID WP_000323025.1
Coordinates 2247703..2247990 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag CA901_RS10845 Protein ID WP_000534858.1
Coordinates 2247464..2247703 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA901_RS10815 (2242527) 2242527..2242829 + 303 Protein_2114 DUF977 family protein -
CA901_RS10820 (2242826) 2242826..2243315 + 490 Protein_2115 SAM-dependent methyltransferase -
CA901_RS10825 (2243793) 2243793..2244214 + 422 Protein_2116 hypothetical protein -
CA901_RS10830 (2244870) 2244870..2245892 + 1023 Protein_2117 ISNCY family transposase -
CA901_RS24545 (2246013) 2246013..2246162 + 150 WP_011443592.1 protein YdfW -
CA901_RS10835 (2246599) 2246599..2246931 - 333 WP_001301033.1 FlxA-like family protein -
CA901_RS10840 (2247134) 2247134..2247439 - 306 WP_001326990.1 protein YdfV -
CA901_RS10845 (2247464) 2247464..2247703 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
CA901_RS10850 (2247703) 2247703..2247990 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
CA901_RS10855 (2248062) 2248062..2248217 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
CA901_RS10860 (2248434) 2248434..2248685 + 252 WP_000980994.1 protein Rem -
CA901_RS10865 (2248752) 2248752..2249030 + 279 WP_012304870.1 hypothetical protein -
CA901_RS10870 (2249032) 2249032..2250081 + 1050 WP_001265199.1 DUF968 domain-containing protein -
CA901_RS10875 (2250095) 2250095..2250848 + 754 Protein_2127 antitermination protein -
CA901_RS10880 (2251126) 2251126..2251215 - 90 WP_120795389.1 hypothetical protein -
CA901_RS10885 (2251270) 2251270..2251482 - 213 WP_000087756.1 cold shock-like protein CspF -
CA901_RS10890 (2251783) 2251783..2251998 + 216 WP_000066484.1 cold shock-like protein CspB -
CA901_RS10895 (2252362) 2252362..2252532 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
CA901_RS10900 (2252752) 2252752..2252967 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2220981..2278880 57899


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T136470 WP_000323025.1 NZ_CP042893:2247703-2247990 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T136470 NZ_CP042893:2247703-2247990 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT136470 WP_000534858.1 NZ_CP042893:2247464-2247703 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT136470 NZ_CP042893:2247464-2247703 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References