264756

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2096555..2097081 Replicon chromosome
Accession NZ_CP111004
Organism Escherichia coli strain J53-p131

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag ORI86_RS10210 Protein ID WP_000323025.1
Coordinates 2096794..2097081 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag ORI86_RS10205 Protein ID WP_000534858.1
Coordinates 2096555..2096794 (+) Length 80 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORI86_RS10145 (2091582) 2091582..2092349 - 768 Protein_1980 exonuclease -
ORI86_RS10150 (2092442) 2092442..2092633 - 192 WP_001083297.1 lysis protein YdfD -
ORI86_RS10155 (2092630) 2092630..2092818 - 189 WP_000854559.1 cell division inhibition protein DicB -
ORI86_RS10160 (2093386) 2093386..2093604 - 219 WP_001171942.1 protein YdfC -
ORI86_RS10165 (2093634) 2093634..2093762 - 129 WP_000344964.1 protein YdfB -
ORI86_RS10170 (2093764) 2093764..2093919 - 156 WP_000379575.1 DUF1391 family protein -
ORI86_RS10175 (2094086) 2094086..2094493 - 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
ORI86_RS10180 (2094577) 2094577..2094807 + 231 WP_000920568.1 dicB transcriptional regulator DicC -
ORI86_RS10185 (2094791) 2094791..2095069 + 279 Protein_1988 hypothetical protein -
ORI86_RS10190 (2095104) 2095104..2095253 + 150 WP_011443592.1 protein YdfW -
ORI86_RS10195 (2095690) 2095690..2096022 - 333 WP_001301033.1 FlxA-like family protein -
ORI86_RS10200 (2096225) 2096225..2096530 - 306 WP_001326990.1 protein YdfV -
ORI86_RS10205 (2096555) 2096555..2096794 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
ORI86_RS10210 (2096794) 2096794..2097081 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
ORI86_RS10215 (2097153) 2097153..2097308 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
ORI86_RS10220 (2097525) 2097525..2097776 + 252 WP_000980994.1 protein Rem -
ORI86_RS10225 (2097843) 2097843..2098121 + 279 WP_012304870.1 hypothetical protein -
ORI86_RS10230 (2098123) 2098123..2099172 + 1050 WP_001265198.1 DUF968 domain-containing protein -
ORI86_RS10235 (2099186) 2099186..2099938 + 753 WP_001047135.1 antitermination protein -
ORI86_RS10240 (2100216) 2100216..2100305 - 90 WP_120795389.1 hypothetical protein -
ORI86_RS10245 (2100360) 2100360..2100572 - 213 WP_000087756.1 cold shock-like protein CspF -
ORI86_RS10250 (2100873) 2100873..2101088 + 216 WP_000066484.1 cold shock-like protein CspB -
ORI86_RS10255 (2101452) 2101452..2101622 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
ORI86_RS10260 (2101842) 2101842..2102057 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2077964..2118322 40358
- inside Prophage - - 2084557..2122438 37881


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T264756 WP_000323025.1 NZ_CP111004:2096794-2097081 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp


Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT264756 WP_000534858.1 NZ_CP111004:2096555-2096794 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9


Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References