Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2379420..2379946 | Replicon | chromosome |
| Accession | NZ_CP080223 | ||
| Organism | Escherichia coli O141:H4 strain P13-6 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | KZW89_RS11790 | Protein ID | WP_000323025.1 |
| Coordinates | 2379659..2379946 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | KZW89_RS11785 | Protein ID | WP_000534858.1 |
| Coordinates | 2379420..2379659 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KZW89_RS11755 (2374534) | 2374534..2374785 | + | 252 | Protein_2307 | DUF977 family protein | - |
| KZW89_RS11760 (2374782) | 2374782..2375271 | + | 490 | Protein_2308 | SAM-dependent methyltransferase | - |
| KZW89_RS11765 (2375749) | 2375749..2376170 | + | 422 | Protein_2309 | hypothetical protein | - |
| KZW89_RS11770 (2376826) | 2376826..2377848 | + | 1023 | Protein_2310 | ISNCY family transposase | - |
| KZW89_RS28815 (2377969) | 2377969..2378118 | + | 150 | WP_011443592.1 | protein YdfW | - |
| KZW89_RS11775 (2378555) | 2378555..2378887 | - | 333 | WP_001301033.1 | FlxA-like family protein | - |
| KZW89_RS11780 (2379090) | 2379090..2379395 | - | 306 | WP_001326990.1 | protein YdfV | - |
| KZW89_RS11785 (2379420) | 2379420..2379659 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| KZW89_RS11790 (2379659) | 2379659..2379946 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| KZW89_RS11795 (2380018) | 2380018..2380173 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| KZW89_RS11800 (2380390) | 2380390..2380641 | + | 252 | WP_000980994.1 | protein Rem | - |
| KZW89_RS11805 (2380708) | 2380708..2380986 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| KZW89_RS11810 (2380988) | 2380988..2382037 | + | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| KZW89_RS11815 (2382051) | 2382051..2382803 | + | 753 | WP_001047135.1 | antitermination protein | - |
| KZW89_RS11820 (2383081) | 2383081..2383170 | - | 90 | WP_120795389.1 | hypothetical protein | - |
| KZW89_RS11825 (2383225) | 2383225..2383437 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| KZW89_RS11830 (2383738) | 2383738..2383953 | + | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| KZW89_RS11835 (2384317) | 2384317..2384487 | - | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| KZW89_RS11840 (2384707) | 2384707..2384922 | + | 216 | WP_000839590.1 | phage lysis protein EssD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| inside | Prophage | - | - | 2354039..2411274 | 57235 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T211257 WP_000323025.1 NZ_CP080223:2379659-2379946 [Escherichia coli O141:H4]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T211257 NZ_CP104788:3501850-3502314 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT211257 WP_000534858.1 NZ_CP080223:2379420-2379659 [Escherichia coli O141:H4]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT211257 NZ_CP104788:3501515-3501850 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|