Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2049409..2049935 | Replicon | chromosome |
| Accession | NZ_CP009685 | ||
| Organism | Escherichia coli str. K-12 substr. MG1655 strain K-12 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | EO53_RS10155 | Protein ID | WP_000323025.1 |
| Coordinates | 2049648..2049935 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | EO53_RS10150 | Protein ID | WP_000534858.1 |
| Coordinates | 2049409..2049648 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EO53_RS23865 | 2044436..2045203 | - | 768 | Protein_1916 | exonuclease | - |
| EO53_RS10105 | 2045296..2045487 | - | 192 | WP_001083297.1 | lysis protein YdfD | - |
| EO53_RS10110 | 2045484..2045672 | - | 189 | WP_000854559.1 | cell division inhibition protein DicB | - |
| EO53_RS10120 | 2046240..2046458 | - | 219 | WP_001171942.1 | hypothetical protein | - |
| EO53_RS10125 | 2046618..2046773 | - | 156 | WP_000379575.1 | DUF1391 family protein | - |
| EO53_RS10130 | 2046940..2047347 | - | 408 | WP_000448564.1 | DNA-binding transcriptional dual regulator DicA | - |
| EO53_RS10135 | 2047431..2047661 | + | 231 | WP_000920568.1 | dicB transcriptional regulator DicC | - |
| EO53_RS10140 | 2047645..2047923 | + | 279 | Protein_1923 | hypothetical protein | - |
| EO53_RS23065 | 2047958..2048107 | + | 150 | WP_011443592.1 | hypothetical protein | - |
| EO53_RS10145 | 2048544..2048876 | - | 333 | WP_001301033.1 | protein FlxA | - |
| EO53_RS23880 | 2049079..2049384 | - | 306 | WP_001326990.1 | hypothetical protein | - |
| EO53_RS10150 | 2049409..2049648 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| EO53_RS10155 | 2049648..2049935 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| EO53_RS10160 | 2050007..2050162 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| EO53_RS10165 | 2050379..2050630 | + | 252 | WP_000980994.1 | hypothetical protein | - |
| EO53_RS10170 | 2050697..2050975 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| EO53_RS10175 | 2050977..2052026 | + | 1050 | WP_001393597.1 | DUF968 domain-containing protein | - |
| EO53_RS10180 | 2052040..2052792 | + | 753 | WP_001047135.1 | antitermination protein | - |
| EO53_RS25685 | 2053070..2053159 | - | 90 | WP_120795389.1 | hypothetical protein | - |
| EO53_RS10185 | 2053214..2053426 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| EO53_RS10190 | 2053727..2053942 | + | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| EO53_RS10195 | 2054696..2054911 | + | 216 | WP_000839590.1 | phage lysis protein EssD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| inside | Prophage | - | - | 2025689..2080477 | 54788 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T49444 WP_000323025.1 NZ_CP009685:2049648-2049935 [Escherichia coli str. K-12 substr. MG1655]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T49444 NZ_CP009685:2049648-2049935 [Escherichia coli str. K-12 substr. MG1655]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT49444 WP_000534858.1 NZ_CP009685:2049409-2049648 [Escherichia coli str. K-12 substr. MG1655]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT49444 NZ_CP009685:2049409-2049648 [Escherichia coli str. K-12 substr. MG1655]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|