246500

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2847576..2848102 Replicon chromosome
Accession NZ_CP097884
Organism Escherichia coli str. K-12 substr. MG1655 strain K-12

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag NAG72_RS13675 Protein ID WP_000323025.1
Coordinates 2847815..2848102 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag NAG72_RS13670 Protein ID WP_000534858.1
Coordinates 2847576..2847815 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NAG72_RS13610 (2842603) 2842603..2843370 - 768 Protein_2638 exonuclease -
NAG72_RS13615 (2843463) 2843463..2843654 - 192 WP_001083297.1 lysis protein YdfD -
NAG72_RS13620 (2843651) 2843651..2843839 - 189 WP_000854559.1 cell division inhibition protein DicB -
NAG72_RS13625 (2844407) 2844407..2844625 - 219 WP_001171942.1 protein YdfC -
NAG72_RS13630 (2844655) 2844655..2844783 - 129 WP_000344964.1 protein YdfB -
NAG72_RS13635 (2844785) 2844785..2844940 - 156 WP_000379575.1 DUF1391 family protein -
NAG72_RS13640 (2845107) 2845107..2845514 - 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
NAG72_RS13645 (2845598) 2845598..2845828 + 231 WP_000920568.1 dicB transcriptional regulator DicC -
NAG72_RS13650 (2845812) 2845812..2846090 + 279 Protein_2646 hypothetical protein -
NAG72_RS13655 (2846125) 2846125..2846274 + 150 WP_011443592.1 protein YdfW -
NAG72_RS13660 (2846711) 2846711..2847043 - 333 WP_001301033.1 FlxA-like family protein -
NAG72_RS13665 (2847246) 2847246..2847551 - 306 WP_001326990.1 protein YdfV -
NAG72_RS13670 (2847576) 2847576..2847815 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
NAG72_RS13675 (2847815) 2847815..2848102 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
NAG72_RS13680 (2848174) 2848174..2848329 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
NAG72_RS13685 (2848546) 2848546..2848797 + 252 WP_000980994.1 protein Rem -
NAG72_RS13690 (2848864) 2848864..2849142 + 279 WP_012304870.1 hypothetical protein -
NAG72_RS13695 (2849144) 2849144..2850193 + 1050 WP_001393597.1 DUF968 domain-containing protein -
NAG72_RS13700 (2850207) 2850207..2850959 + 753 WP_001047135.1 antitermination protein -
NAG72_RS13705 (2851237) 2851237..2851326 - 90 WP_120795389.1 hypothetical protein -
NAG72_RS13710 (2851381) 2851381..2851593 - 213 WP_000087756.1 cold shock-like protein CspF -
NAG72_RS13715 (2851894) 2851894..2852109 + 216 WP_000066484.1 cold shock-like protein CspB -
NAG72_RS13720 (2852473) 2852473..2852643 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
NAG72_RS13725 (2852863) 2852863..2853078 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2828985..2869343 40358


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T246500 WP_000323025.1 NZ_CP097884:2847815-2848102 [Escherichia coli str. K-12 substr. MG1655]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT246500 WP_000534858.1 NZ_CP097884:2847576-2847815 [Escherichia coli str. K-12 substr. MG1655]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References