137642

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4218550..4219076 Replicon chromosome
Accession NZ_CP043197
Organism Escherichia coli O16:H48 strain PG20180061

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag FYA12_RS20495 Protein ID WP_000323025.1
Coordinates 4218789..4219076 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag FYA12_RS20490 Protein ID WP_000534858.1
Coordinates 4218550..4218789 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYA12_RS20430 4213577..4214344 - 768 Protein_3959 exonuclease -
FYA12_RS20435 4214437..4214628 - 192 WP_001083297.1 lysis protein YdfD -
FYA12_RS20440 4214625..4214813 - 189 WP_000854559.1 cell division inhibition protein DicB -
FYA12_RS20450 4215381..4215599 - 219 WP_001171942.1 hypothetical protein -
FYA12_RS20455 4215759..4215914 - 156 WP_000379575.1 DUF1391 family protein -
FYA12_RS20460 4216081..4216488 - 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
FYA12_RS20465 4216572..4216802 + 231 WP_000920568.1 dicB transcriptional regulator DicC -
FYA12_RS20470 4216786..4217064 + 279 Protein_3966 hypothetical protein -
FYA12_RS20475 4217099..4217248 + 150 WP_011443592.1 hypothetical protein -
FYA12_RS20480 4217685..4218017 - 333 WP_001301033.1 protein FlxA -
FYA12_RS20485 4218220..4218525 - 306 WP_001326990.1 hypothetical protein -
FYA12_RS20490 4218550..4218789 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
FYA12_RS20495 4218789..4219076 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
FYA12_RS20500 4219148..4219303 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
FYA12_RS20505 4219520..4219771 + 252 WP_000980994.1 hypothetical protein -
FYA12_RS20510 4219838..4220116 + 279 WP_012304870.1 hypothetical protein -
FYA12_RS20515 4220118..4221167 + 1050 WP_001265198.1 DUF968 domain-containing protein -
FYA12_RS20520 4221181..4221933 + 753 WP_001047135.1 antitermination protein -
FYA12_RS20525 4222211..4222300 - 90 WP_120795389.1 hypothetical protein -
FYA12_RS20530 4222355..4222567 - 213 WP_000087756.1 cold shock-like protein CspF -
FYA12_RS20535 4222868..4223083 + 216 WP_000066484.1 cold shock-like protein CspB -
FYA12_RS23050 4223447..4223617 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
FYA12_RS20540 4223837..4224052 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 4199959..4240317 40358


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T137642 WP_000323025.1 NZ_CP043197:4218789-4219076 [Escherichia coli O16:H48]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T137642 NZ_CP056855:c141346-141059 [Klebsiella pneumoniae]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT137642 WP_000534858.1 NZ_CP043197:4218550-4218789 [Escherichia coli O16:H48]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT137642 NZ_CP056855:c141585-141346 [Klebsiella pneumoniae]
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTTGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References