Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1680162..1680688 Replicon chromosome
Accession NZ_CP068283
Organism Escherichia coli strain CY598

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag JI738_RS08345 Protein ID WP_000323025.1
Coordinates 1680162..1680449 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag JI738_RS08350 Protein ID WP_000534858.1
Coordinates 1680449..1680688 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JI738_RS08295 (1675186) 1675186..1675401 - 216 WP_000839590.1 phage lysis protein EssD -
JI738_RS08300 (1675621) 1675621..1675791 + 171 WP_211180497.1 putative zinc-binding protein YnfU -
JI738_RS08305 (1676155) 1676155..1676370 - 216 WP_000066484.1 cold shock-like protein CspB -
JI738_RS08310 (1676671) 1676671..1676883 + 213 WP_000087756.1 cold shock-like protein CspF -
JI738_RS08315 (1676938) 1676938..1677027 + 90 WP_120795389.1 hypothetical protein -
JI738_RS08320 (1677305) 1677305..1678057 - 753 WP_001047135.1 antitermination protein -
JI738_RS08325 (1678071) 1678071..1679120 - 1050 WP_001265198.1 DUF968 domain-containing protein -
JI738_RS08330 (1679122) 1679122..1679400 - 279 WP_012304870.1 hypothetical protein -
JI738_RS08335 (1679467) 1679467..1679718 - 252 WP_000980994.1 protein Rem -
JI738_RS08340 (1679935) 1679935..1680090 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
JI738_RS08345 (1680162) 1680162..1680449 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
JI738_RS08350 (1680449) 1680449..1680688 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
JI738_RS08355 (1680713) 1680713..1681018 + 306 WP_001326990.1 protein YdfV -
JI738_RS08360 (1681221) 1681221..1681553 + 333 WP_001301033.1 FlxA-like family protein -
JI738_RS08365 (1681990) 1681990..1682139 - 150 WP_011443592.1 protein YdfW -
JI738_RS08370 (1682174) 1682174..1682452 - 279 Protein_1644 hypothetical protein -
JI738_RS08375 (1682436) 1682436..1682666 - 231 WP_000920568.1 dicB transcriptional regulator DicC -
JI738_RS08380 (1682750) 1682750..1683157 + 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
JI738_RS08385 (1683324) 1683324..1683479 + 156 WP_000379575.1 DUF1391 family protein -
JI738_RS23325 (1683481) 1683481..1683609 + 129 WP_000344964.1 protein YdfB -
JI738_RS08390 (1683639) 1683639..1683857 + 219 WP_001171942.1 protein YdfC -
JI738_RS08395 (1684425) 1684425..1684613 + 189 WP_000854559.1 cell division inhibition protein DicB -
JI738_RS08400 (1684610) 1684610..1684801 + 192 WP_001083297.1 lysis protein YdfD -
JI738_RS08405 (1684894) 1684894..1685661 + 768 Protein_1652 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1649619..1705744 56125


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T187096 WP_000323025.1 NZ_CP068283:c1680449-1680162 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T187096 NZ_CP089777:c3152022-3151138 [Mycobacterium tuberculosis]
GTGGCCGGTCTGACCCGTGCGCTCGTTGCGCGTCACGCTCTTGGTCGGGCCGAGGCATACGACGCCGCTCTGCTCGACGT
CGCCCAGGACCACCTGCTGTACCTGCTGTCGCAGACCGTCCAGTTCGGCGATAACCGCCTGGTGTTCAAAGGCGGTACCA
GCTTACGGAAGTGCCGGCTGGGCAACGTCGGGCGGTTCTCCACTGATCTGGACTTCAGCGCGCCCGACGATGAGGTCGTG
CTGGAGGTGTGCGAGCTGATCGACGGCGCCCGTGTCGGCGGCTTCGAATTCGGCGTGCAGAGCACACGAGGCGACGGCCG
GCATTGGCAGTTGCGGGTGCGGCACACGGAATTGGGCGAGCCCCGGATCGTCGCCAGCGTCGAGTTCGCACGGCGGCCGT
TGGCTTTGCCGTCTGAGCTGCTCGCATTCATCCAGTTGCCGATCCATAAGGCTTACGGTTTTGGGCTGCCGACACTGCCG
GTCGTGGCAGAAGCGGAAGCCTGCGCAGAGAAACTCGCGCGGTACCGCCGCGTTGCGCTGGCACGGGACCTGTACGACCT
GAACCACTTCGCCTCGCGAACGATTGACGAACCGCTCGTGCGGCGGCTGTGGGTGCTCAAGGTGTGGGGTGATGTCGTCG
ATGACCGGCGCGGCACCCGGCCACTACGCGTCGAAGACGTCCTCGCCGCCCGCAGCGAGCACGACTTCCAGCCCGACTCG
ATCGGCGTGCTGACCCGTCCTGTCGCTATGGCTGCCTGGGAAGCTCGCGTTCGGAAGCGATTTGCGTTCCTCACTGACCT
CGACGCCGACGAGCAGCGGTGGGCCGCCTGCGACGAACGGCACCGCCGCGAAGTGGAGAACGCGCTGGCGGTGCTGCGGT
CCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT187096 WP_000534858.1 NZ_CP068283:c1680688-1680449 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT187096 NZ_CP089777:c3152912-3152025 [Mycobacterium tuberculosis]
GTGGTGAGCCCAGCCGGCGCCGATCGGCGCATCCCCACGTGGGCGTCACGGGTGGTGTCCGGCCTCGCTCGCGATCGGCC
CGTAGTCGTCACGAAAGAGGATCTGACGCAACGGCTTACAGAGGCTGGGTGTGGACGCGACCCCGACTCCGCCATCCGCG
AACTGCGCCGCATTGGGTGGCTGGTCCAACTGCCGGTGAAAGGCACCTGGGCATTCATTCCCCCCGGCGAGGCCGCCATC
TCGGACCCGTATCTACCGCTGCGCTCGTGGCTGGCCCGTGACCAGAACGCGGGCTTCATGCTGGCCGGTGCATCCGCAGC
GTGGCACCTCGGATACCTGGACCGCCAACCCGACGGCCGCATCCCGATCTGGCTGCCGCCGGCCAAAAGGCTGCCCGACG
GCCTAGCATCGTATGTGTCCGTCGTGCGCATCCCCTGGAACGCGGCGGACACCGCACTGCTGGCTCCGCGTCCCGCGTTG
CTGGTCCGGCGGCGGCTCGACCTCGTCGCGTGGGCGACCGGGTTACCGGCGCTAGGACCAGAAGCATTACTTGTGCAAAT
CGCCACGCGCCCGGCCTCGTTCGGGCCGTGGGCCGACCTTGTCCCCCACCTTGACGACCTCGTCGCCGACTGCAGTGACG
AGCGCCTGGAGCGTCTACTGTCGGGCCGGCCGACATCGGCCTGGCAGCGTGCAAGCTACCTGCTGGACTCGGGCGGTGAA
CCGGCACGAGGCCAGGCGCTGCTGGCCAAGCGGCACACCGAAGTGATGCCGGTGACTCGATTCACCACCGCGCACAGCCG
CGACCGTGGCGAGAGTGTCTGGGCTCCCGAGTATCAGCTTGTCGACGAGCTCGTCGTACCGCTGCTGCGCGTGATCGGCA
AGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References