Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2388143..2388669 | Replicon | chromosome |
| Accession | NZ_CP010443 | ||
| Organism | Escherichia coli K-12 strain K-12 MG1655 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | SH04_RS11795 | Protein ID | WP_000323025.1 |
| Coordinates | 2388143..2388430 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | SH04_RS11800 | Protein ID | WP_000534858.1 |
| Coordinates | 2388430..2388669 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SH04_RS11755 | 2383167..2383382 | - | 216 | WP_000839590.1 | phage lysis protein EssD | - |
| SH04_RS11760 | 2384136..2384351 | - | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| SH04_RS11765 | 2384652..2384864 | + | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| SH04_RS25570 | 2384919..2385008 | + | 90 | WP_120795389.1 | hypothetical protein | - |
| SH04_RS11770 | 2385286..2386038 | - | 753 | WP_001047135.1 | antitermination protein | - |
| SH04_RS11775 | 2386052..2387101 | - | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| SH04_RS11780 | 2387103..2387381 | - | 279 | WP_012304870.1 | hypothetical protein | - |
| SH04_RS11785 | 2387448..2387699 | - | 252 | WP_000980994.1 | hypothetical protein | - |
| SH04_RS11790 | 2387916..2388071 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| SH04_RS11795 | 2388143..2388430 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| SH04_RS11800 | 2388430..2388669 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| SH04_RS24010 | 2388694..2388999 | + | 306 | WP_001326990.1 | hypothetical protein | - |
| SH04_RS11805 | 2389202..2389534 | + | 333 | WP_001301033.1 | protein FlxA | - |
| SH04_RS22970 | 2389971..2390120 | - | 150 | WP_011443592.1 | hypothetical protein | - |
| SH04_RS11810 | 2390155..2390433 | - | 279 | Protein_2225 | hypothetical protein | - |
| SH04_RS11815 | 2390417..2390647 | - | 231 | WP_000920568.1 | dicB transcriptional regulator DicC | - |
| SH04_RS11820 | 2390731..2391138 | + | 408 | WP_000448564.1 | DNA-binding transcriptional dual regulator DicA | - |
| SH04_RS11825 | 2391305..2391460 | + | 156 | WP_000379575.1 | DUF1391 family protein | - |
| SH04_RS11830 | 2391620..2391838 | + | 219 | WP_001171942.1 | hypothetical protein | - |
| SH04_RS11840 | 2392406..2392594 | + | 189 | WP_000854559.1 | cell division inhibition protein DicB | - |
| SH04_RS11845 | 2392591..2392782 | + | 192 | WP_038432577.1 | lysis protein YdfD | - |
| SH04_RS24025 | 2392875..2393642 | + | 768 | Protein_2232 | exonuclease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| inside | Prophage | - | - | 2357601..2412389 | 54788 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T52631 WP_000323025.1 NZ_CP010443:c2388430-2388143 [Escherichia coli K-12]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T52631 NZ_CP010443:c2388430-2388143 [Escherichia coli K-12]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT52631 WP_000534858.1 NZ_CP010443:c2388669-2388430 [Escherichia coli K-12]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT52631 NZ_CP010443:c2388669-2388430 [Escherichia coli K-12]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|