137602

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2526863..2527389 Replicon chromosome
Accession NZ_CP043195
Organism Escherichia coli O16:H48 strain PG20180062

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag FYA13_RS12180 Protein ID WP_000323025.1
Coordinates 2527102..2527389 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag FYA13_RS12175 Protein ID WP_000534858.1
Coordinates 2526863..2527102 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYA13_RS12115 2521890..2522657 - 768 Protein_2346 exonuclease -
FYA13_RS12120 2522750..2522941 - 192 WP_001083297.1 lysis protein YdfD -
FYA13_RS12125 2522938..2523126 - 189 WP_000854559.1 cell division inhibition protein DicB -
FYA13_RS12135 2523694..2523912 - 219 WP_001171942.1 hypothetical protein -
FYA13_RS12140 2524072..2524227 - 156 WP_000379575.1 DUF1391 family protein -
FYA13_RS12145 2524394..2524801 - 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
FYA13_RS12150 2524885..2525115 + 231 WP_000920568.1 dicB transcriptional regulator DicC -
FYA13_RS12155 2525099..2525377 + 279 Protein_2353 hypothetical protein -
FYA13_RS12160 2525412..2525561 + 150 WP_011443592.1 hypothetical protein -
FYA13_RS12165 2525998..2526330 - 333 WP_001301033.1 protein FlxA -
FYA13_RS12170 2526533..2526838 - 306 WP_001326990.1 hypothetical protein -
FYA13_RS12175 2526863..2527102 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
FYA13_RS12180 2527102..2527389 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
FYA13_RS12185 2527461..2527616 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
FYA13_RS12190 2527833..2528084 + 252 WP_000980994.1 hypothetical protein -
FYA13_RS12195 2528151..2528429 + 279 WP_012304870.1 hypothetical protein -
FYA13_RS12200 2528431..2529480 + 1050 WP_001265198.1 DUF968 domain-containing protein -
FYA13_RS12205 2529494..2530246 + 753 WP_001047135.1 antitermination protein -
FYA13_RS12210 2530524..2530613 - 90 WP_120795389.1 hypothetical protein -
FYA13_RS12215 2530668..2530880 - 213 WP_000087756.1 cold shock-like protein CspF -
FYA13_RS12220 2531181..2531396 + 216 WP_000066484.1 cold shock-like protein CspB -
FYA13_RS23350 2531760..2531930 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
FYA13_RS12225 2532150..2532365 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2508272..2548630 40358


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T137602 WP_000323025.1 NZ_CP043195:2527102-2527389 [Escherichia coli O16:H48]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T137602 NZ_CP043195:2527102-2527389 [Escherichia coli O16:H48]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT137602 WP_000534858.1 NZ_CP043195:2526863-2527102 [Escherichia coli O16:H48]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT137602 NZ_CP056839:c4730643-4730401 [Citrobacter freundii]
ATGATGGCTGGGATGGATATGGGCAGAATTTTACTCGATTTATCAGATGAAGTGATTAAACGTCTTGATGATCTCAAGGT
GCAGCGCAACCTGCCGCGAGCAGAACTTTTACGGGAGGCCGTTGAACAGTATCTTGAGAGGCAGGATCAGGCTGAAACCA
CAATTTCACGTGCTCTTGGGCTGTGGCAAGGCTGTGAGGAAGATGGTGTTGAATACCAGCGTAAACTCCGTGAGGAATGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References