Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2204830..2205356 | Replicon | chromosome |
| Accession | NZ_CP048439 | ||
| Organism | Escherichia coli strain NBRC 3301 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | GXM24_RS10630 | Protein ID | WP_000323025.1 |
| Coordinates | 2205069..2205356 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | GXM24_RS10625 | Protein ID | WP_000534858.1 |
| Coordinates | 2204830..2205069 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GXM24_RS10565 | 2199857..2200624 | - | 768 | Protein_2056 | exonuclease | - |
| GXM24_RS10570 | 2200717..2200908 | - | 192 | WP_001083297.1 | lysis protein YdfD | - |
| GXM24_RS10575 | 2200905..2201093 | - | 189 | WP_000854559.1 | cell division inhibition protein DicB | - |
| GXM24_RS10585 | 2201661..2201879 | - | 219 | WP_001171942.1 | hypothetical protein | - |
| GXM24_RS10590 | 2202039..2202194 | - | 156 | WP_000379575.1 | DUF1391 family protein | - |
| GXM24_RS10595 | 2202361..2202768 | - | 408 | WP_000448564.1 | DNA-binding transcriptional dual regulator DicA | - |
| GXM24_RS10600 | 2202852..2203082 | + | 231 | WP_000920568.1 | dicB transcriptional regulator DicC | - |
| GXM24_RS10605 | 2203066..2203344 | + | 279 | Protein_2063 | hypothetical protein | - |
| GXM24_RS10610 | 2203379..2203528 | + | 150 | WP_011443592.1 | hypothetical protein | - |
| GXM24_RS10615 | 2203965..2204297 | - | 333 | WP_001301033.1 | protein FlxA | - |
| GXM24_RS10620 | 2204500..2204805 | - | 306 | WP_001326990.1 | hypothetical protein | - |
| GXM24_RS10625 | 2204830..2205069 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| GXM24_RS10630 | 2205069..2205356 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| GXM24_RS10635 | 2205428..2205583 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| GXM24_RS10640 | 2205800..2206051 | + | 252 | WP_000980994.1 | hypothetical protein | - |
| GXM24_RS10645 | 2206118..2206396 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| GXM24_RS10650 | 2206398..2207447 | + | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| GXM24_RS10655 | 2207461..2208213 | + | 753 | WP_001047135.1 | antitermination protein | - |
| GXM24_RS10660 | 2208491..2208580 | - | 90 | WP_120795389.1 | hypothetical protein | - |
| GXM24_RS10665 | 2208635..2208847 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| GXM24_RS10670 | 2209148..2209363 | + | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| GXM24_RS10675 | 2210117..2210332 | + | 216 | WP_000839590.1 | phage lysis protein EssD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| inside | Prophage | - | - | 2181110..2235898 | 54788 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T149472 WP_000323025.1 NZ_CP048439:2205069-2205356 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T149472 NZ_CP064113:c303606-303304 [Enterobacter hormaechei]
ATGAAGGAGATCGTTCAGACAGAATCCTTCCGACGCTGGGAGCAAAATTTAAAGGACAGGCGGGCAAAGACGATTATCGC
TTCCCGCCTCTTTAGGCTGGCAAATGGCTTAGCGGGCGACATTAGACCCGTGGGGGAAGGTATCAGTGAACTGAGGATCC
ACTTTGGCCCGGGCTACAGAGTCTATTTTAAGGACCAGGGCAATTGCATCATCGTGCTGTTATGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTTATGGCAAAAATGCTGAGCAATGTATCCCAATGGCAGGAGTGA
ATGAAGGAGATCGTTCAGACAGAATCCTTCCGACGCTGGGAGCAAAATTTAAAGGACAGGCGGGCAAAGACGATTATCGC
TTCCCGCCTCTTTAGGCTGGCAAATGGCTTAGCGGGCGACATTAGACCCGTGGGGGAAGGTATCAGTGAACTGAGGATCC
ACTTTGGCCCGGGCTACAGAGTCTATTTTAAGGACCAGGGCAATTGCATCATCGTGCTGTTATGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTTATGGCAAAAATGCTGAGCAATGTATCCCAATGGCAGGAGTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT149472 WP_000534858.1 NZ_CP048439:2204830-2205069 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT149472 NZ_CP064113:c303297-303010 [Enterobacter hormaechei]
ATGCATAAATTAACACCCTACGATCCAGCCAACGCACTGGTGGATGACGAGGAAATCGCTGTGTTTATGGCTGATGCATT
AGAGACGGGTGACTCAGCGTACATTGCTAAAGCGCTGGGCGTCATCGCCCGAGCGAAAGGGATGTCGACCATTTCCCTGC
AAACGGGCCTGTCACGAGAACAACTGTATCGATCATTCAGTGATAAGGGGAACCCAACGCTCAAAACCACGCTGGCGGTC
ATGAAAGCATTGGGCCTTAGGTTAACAATCAAACCCTCTGGGGATTAA
ATGCATAAATTAACACCCTACGATCCAGCCAACGCACTGGTGGATGACGAGGAAATCGCTGTGTTTATGGCTGATGCATT
AGAGACGGGTGACTCAGCGTACATTGCTAAAGCGCTGGGCGTCATCGCCCGAGCGAAAGGGATGTCGACCATTTCCCTGC
AAACGGGCCTGTCACGAGAACAACTGTATCGATCATTCAGTGATAAGGGGAACCCAACGCTCAAAACCACGCTGGCGGTC
ATGAAAGCATTGGGCCTTAGGTTAACAATCAAACCCTCTGGGGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|