260336

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2246797..2247323 Replicon chromosome
Accession NZ_CP107003
Organism Escherichia coli strain SY22B1

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag OFB13_RS10945 Protein ID WP_000323025.1
Coordinates 2247036..2247323 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag OFB13_RS10940 Protein ID WP_000534858.1
Coordinates 2246797..2247036 (+) Length 80 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OFB13_RS10880 (2241824) 2241824..2242591 - 768 Protein_2125 exonuclease -
OFB13_RS10885 (2242684) 2242684..2242875 - 192 WP_001083297.1 lysis protein YdfD -
OFB13_RS10890 (2242872) 2242872..2243060 - 189 WP_000854559.1 cell division inhibition protein DicB -
OFB13_RS10895 (2243628) 2243628..2243846 - 219 WP_001171942.1 protein YdfC -
OFB13_RS10900 (2243876) 2243876..2244004 - 129 WP_000344964.1 protein YdfB -
OFB13_RS10905 (2244006) 2244006..2244161 - 156 WP_000379575.1 DUF1391 family protein -
OFB13_RS10910 (2244328) 2244328..2244735 - 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
OFB13_RS10915 (2244819) 2244819..2245049 + 231 WP_000920568.1 dicB transcriptional regulator DicC -
OFB13_RS10920 (2245033) 2245033..2245311 + 279 Protein_2133 protein YdfX -
OFB13_RS10925 (2245346) 2245346..2245495 + 150 WP_011443592.1 protein YdfW -
OFB13_RS10930 (2245932) 2245932..2246264 - 333 WP_001301033.1 FlxA-like family protein -
OFB13_RS10935 (2246467) 2246467..2246772 - 306 WP_001326990.1 protein YdfV -
OFB13_RS10940 (2246797) 2246797..2247036 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
OFB13_RS10945 (2247036) 2247036..2247323 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
OFB13_RS10950 (2247395) 2247395..2247550 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
OFB13_RS10955 (2247767) 2247767..2248018 + 252 WP_000980994.1 protein Rem -
OFB13_RS10960 (2248085) 2248085..2248363 + 279 WP_012304870.1 hypothetical protein -
OFB13_RS10965 (2248365) 2248365..2249414 + 1050 WP_001265198.1 DUF968 domain-containing protein -
OFB13_RS10970 (2249428) 2249428..2250180 + 753 WP_001047135.1 antitermination protein -
OFB13_RS10975 (2250458) 2250458..2250547 - 90 WP_120795389.1 hypothetical protein -
OFB13_RS10980 (2250602) 2250602..2250814 - 213 WP_000087756.1 cold shock-like protein CspF -
OFB13_RS10985 (2251115) 2251115..2251330 + 216 WP_000066484.1 cold shock-like protein CspB -
OFB13_RS10990 (2251694) 2251694..2251864 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
OFB13_RS10995 (2252084) 2252084..2252299 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2226870..2268564 41694


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T260336 WP_000323025.1 NZ_CP107003:2247036-2247323 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp


Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT260336 WP_000534858.1 NZ_CP107003:2246797-2247036 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9


Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References