272600

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2602833..2603359 Replicon chromosome
Accession NZ_CP117971
Organism Escherichia coli strain B-1109

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag PT723_RS12590 Protein ID WP_000323025.1
Coordinates 2603072..2603359 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag PT723_RS12585 Protein ID WP_000534858.1
Coordinates 2602833..2603072 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT723_RS12555 (2598195) 2598195..2598684 + 490 Protein_2437 class I SAM-dependent methyltransferase -
PT723_RS12560 (2599162) 2599162..2599583 + 422 Protein_2438 hypothetical protein -
PT723_RS12565 (2600239) 2600239..2601261 + 1023 Protein_2439 ISNCY family transposase -
PT723_RS12570 (2601382) 2601382..2601531 + 150 WP_011443592.1 protein YdfW -
PT723_RS12575 (2601968) 2601968..2602300 - 333 WP_001301033.1 FlxA-like family protein -
PT723_RS12580 (2602503) 2602503..2602808 - 306 WP_001326990.1 protein YdfV -
PT723_RS12585 (2602833) 2602833..2603072 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
PT723_RS12590 (2603072) 2603072..2603359 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
PT723_RS12595 (2603431) 2603431..2603511 + 81 Protein_2445 type I toxin-antitoxin system toxin HokD -
PT723_RS12600 (2603578) 2603578..2604379 + 802 Protein_2446 IS3-like element IS3 family transposase -
PT723_RS12605 (2604441) 2604441..2605490 + 1050 WP_001265198.1 DUF968 domain-containing protein -
PT723_RS12610 (2605504) 2605504..2606256 + 753 WP_001047135.1 antitermination protein -
PT723_RS12615 (2606534) 2606534..2606623 - 90 WP_120795389.1 hypothetical protein -
PT723_RS12620 (2606678) 2606678..2606890 - 213 WP_000087756.1 cold shock-like protein CspF -
PT723_RS12625 (2607191) 2607191..2607406 + 216 WP_000066484.1 cold shock-like protein CspB -
PT723_RS12630 (2607770) 2607770..2607940 - 171 WP_211180497.1 putative zinc-binding protein YnfU -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2577962..2618799 40837


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T272600 WP_000323025.1 NZ_CP117971:2603072-2603359 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT272600 WP_000534858.1 NZ_CP117971:2602833-2603072 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References