235511

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1476215..1476741 Replicon chromosome
Accession NZ_CP092037
Organism Escherichia coli strain MG1655-377GD

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag MBA16_RS07375 Protein ID WP_000323025.1
Coordinates 1476215..1476502 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag MBA16_RS07380 Protein ID WP_000534858.1
Coordinates 1476502..1476741 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MBA16_RS07325 (1471239) 1471239..1471454 - 216 WP_000839590.1 phage lysis protein EssD -
MBA16_RS07330 (1471674) 1471674..1471844 + 171 WP_211180497.1 putative zinc-binding protein YnfU -
MBA16_RS07335 (1472208) 1472208..1472423 - 216 WP_000066484.1 cold shock-like protein CspB -
MBA16_RS07340 (1472724) 1472724..1472936 + 213 WP_000087756.1 cold shock-like protein CspF -
MBA16_RS07345 (1472991) 1472991..1473080 + 90 WP_120795389.1 hypothetical protein -
MBA16_RS07350 (1473358) 1473358..1474110 - 753 WP_001047135.1 antitermination protein -
MBA16_RS07355 (1474124) 1474124..1475173 - 1050 WP_001393597.1 DUF968 domain-containing protein -
MBA16_RS07360 (1475175) 1475175..1475453 - 279 WP_012304870.1 hypothetical protein -
MBA16_RS07365 (1475520) 1475520..1475771 - 252 WP_000980994.1 protein Rem -
MBA16_RS07370 (1475988) 1475988..1476143 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
MBA16_RS07375 (1476215) 1476215..1476502 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
MBA16_RS07380 (1476502) 1476502..1476741 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
MBA16_RS07385 (1476766) 1476766..1477071 + 306 WP_001326990.1 protein YdfV -
MBA16_RS07390 (1477274) 1477274..1477606 + 333 WP_001301033.1 FlxA-like family protein -
MBA16_RS07395 (1478043) 1478043..1478192 - 150 WP_011443592.1 protein YdfW -
MBA16_RS07400 (1478227) 1478227..1478505 - 279 Protein_1440 hypothetical protein -
MBA16_RS07405 (1478489) 1478489..1478719 - 231 WP_000920568.1 dicB transcriptional regulator DicC -
MBA16_RS07410 (1478803) 1478803..1479210 + 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
MBA16_RS07415 (1479377) 1479377..1479532 + 156 WP_000379575.1 DUF1391 family protein -
MBA16_RS21015 (1479534) 1479534..1479662 + 129 WP_000344964.1 protein YdfB -
MBA16_RS07420 (1479692) 1479692..1479910 + 219 WP_001171942.1 protein YdfC -
MBA16_RS07425 (1480478) 1480478..1480666 + 189 WP_000854559.1 cell division inhibition protein DicB -
MBA16_RS07430 (1480663) 1480663..1480854 + 192 WP_001083297.1 lysis protein YdfD -
MBA16_RS07435 (1480947) 1480947..1481714 + 768 Protein_1448 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1454974..1491108 36134


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T235511 WP_000323025.1 NZ_CP092037:c1476502-1476215 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T235511 NZ_LR134296:2300857-2302179 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCAAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACAGCACTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCA
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAAGCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT235511 WP_000534858.1 NZ_CP092037:c1476741-1476502 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT235511 NZ_LR134296:2300591-2300857 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGTATTAAGCAGGCGACGATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAAATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References