93904

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1645345..1645871 Replicon chromosome
Accession NZ_CP026343
Organism Escherichia coli strain 9A

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag C2R20_RS08635 Protein ID WP_000323025.1
Coordinates 1645345..1645632 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag C2R20_RS08640 Protein ID WP_000534858.1
Coordinates 1645632..1645871 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2R20_RS08595 1640369..1640584 - 216 WP_000839590.1 phage lysis protein EssD -
C2R20_RS24440 1640804..1640974 + 171 WP_211180497.1 putative zinc-binding protein YnfU -
C2R20_RS08600 1641338..1641553 - 216 WP_000066484.1 cold shock-like protein CspB -
C2R20_RS08605 1641854..1642066 + 213 WP_000087756.1 cold shock-like protein CspF -
C2R20_RS24165 1642121..1642210 + 90 WP_120795389.1 hypothetical protein -
C2R20_RS08610 1642488..1643240 - 753 WP_001047135.1 antitermination protein -
C2R20_RS08615 1643254..1644303 - 1050 WP_001393597.1 DUF968 domain-containing protein -
C2R20_RS08620 1644305..1644583 - 279 WP_012304870.1 hypothetical protein -
C2R20_RS08625 1644650..1644901 - 252 WP_000980994.1 hypothetical protein -
C2R20_RS08630 1645118..1645273 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
C2R20_RS08635 1645345..1645632 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
C2R20_RS08640 1645632..1645871 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
C2R20_RS08645 1645896..1646201 + 306 WP_001326990.1 hypothetical protein -
C2R20_RS08650 1646404..1646736 + 333 WP_001301033.1 protein FlxA -
C2R20_RS24170 1647173..1647322 - 150 WP_011443592.1 hypothetical protein -
C2R20_RS08660 1647357..1647635 - 279 Protein_1583 hypothetical protein -
C2R20_RS08665 1647619..1647849 - 231 WP_000920568.1 dicB transcriptional regulator DicC -
C2R20_RS08670 1647933..1648340 + 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
C2R20_RS08675 1648507..1648662 + 156 WP_000379575.1 DUF1391 family protein -
C2R20_RS08685 1648822..1649040 + 219 WP_001171942.1 hypothetical protein -
C2R20_RS08695 1649608..1649796 + 189 WP_000854559.1 cell division inhibition protein DicB -
C2R20_RS08700 1649793..1649984 + 192 WP_001083297.1 lysis protein YdfD -
C2R20_RS08705 1650077..1650844 + 768 Protein_1590 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1631001..1664462 33461


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T93904 WP_000323025.1 NZ_CP026343:c1645632-1645345 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T93904 NZ_CP026343:c1645632-1645345 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT93904 WP_000534858.1 NZ_CP026343:c1645871-1645632 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT93904 NZ_CP026343:c1645871-1645632 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References