262667

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1732986..1733512 Replicon chromosome
Accession NZ_CP110015
Organism Escherichia coli strain HE_150

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag OLR73_RS08610 Protein ID WP_000323025.1
Coordinates 1732986..1733273 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag OLR73_RS08615 Protein ID WP_000534858.1
Coordinates 1733273..1733512 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLR73_RS08560 (1728010) 1728010..1728225 - 216 WP_000839590.1 phage lysis protein EssD -
OLR73_RS08565 (1728445) 1728445..1728615 + 171 WP_211180497.1 putative zinc-binding protein YnfU -
OLR73_RS08570 (1728979) 1728979..1729194 - 216 WP_000066484.1 cold shock-like protein CspB -
OLR73_RS08575 (1729495) 1729495..1729707 + 213 WP_000087756.1 cold shock-like protein CspF -
OLR73_RS08580 (1729762) 1729762..1729851 + 90 WP_120795389.1 hypothetical protein -
OLR73_RS08585 (1730129) 1730129..1730881 - 753 WP_001047135.1 antitermination protein -
OLR73_RS08590 (1730895) 1730895..1731944 - 1050 WP_283012269.1 DUF968 domain-containing protein -
OLR73_RS08595 (1731946) 1731946..1732224 - 279 WP_012304870.1 hypothetical protein -
OLR73_RS08600 (1732291) 1732291..1732542 - 252 WP_000980994.1 protein Rem -
OLR73_RS08605 (1732759) 1732759..1732914 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
OLR73_RS08610 (1732986) 1732986..1733273 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
OLR73_RS08615 (1733273) 1733273..1733512 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
OLR73_RS08620 (1733537) 1733537..1733842 + 306 WP_001326990.1 protein YdfV -
OLR73_RS08625 (1734045) 1734045..1734377 + 333 WP_001301033.1 FlxA-like family protein -
OLR73_RS08630 (1734814) 1734814..1734963 - 150 WP_011443592.1 protein YdfW -
OLR73_RS08635 (1734998) 1734998..1735276 - 279 Protein_1689 protein YdfX -
OLR73_RS08640 (1735260) 1735260..1735490 - 231 WP_000920568.1 dicB transcriptional regulator DicC -
OLR73_RS08645 (1735574) 1735574..1735981 + 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
OLR73_RS08650 (1736148) 1736148..1736303 + 156 WP_000379575.1 DUF1391 family protein -
OLR73_RS08655 (1736305) 1736305..1736433 + 129 WP_000344964.1 protein YdfB -
OLR73_RS08660 (1736463) 1736463..1736681 + 219 WP_001171942.1 protein YdfC -
OLR73_RS08665 (1737249) 1737249..1737437 + 189 WP_000854559.1 cell division inhibition protein DicB -
OLR73_RS08670 (1737434) 1737434..1737625 + 192 WP_001083297.1 lysis protein YdfD -
OLR73_RS08675 (1737718) 1737718..1738485 + 768 Protein_1697 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1718642..1753439 34797


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T262667 WP_000323025.1 NZ_CP110015:c1733273-1732986 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT262667 WP_000534858.1 NZ_CP110015:c1733512-1733273 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References