186401

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2240054..2240580 Replicon chromosome
Accession NZ_CP067994
Organism Escherichia coli strain CV601

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag JJT18_RS10765 Protein ID WP_000323025.1
Coordinates 2240293..2240580 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag JJT18_RS10760 Protein ID WP_000534858.1
Coordinates 2240054..2240293 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJT18_RS10705 2235081..2235848 - 768 Protein_2089 exonuclease -
JJT18_RS10710 2235941..2236132 - 192 WP_001083297.1 lysis protein YdfD -
JJT18_RS10715 2236129..2236317 - 189 WP_000854559.1 cell division inhibition protein DicB -
JJT18_RS10720 2236885..2237103 - 219 WP_001171942.1 hypothetical protein -
JJT18_RS10725 2237263..2237418 - 156 WP_000379575.1 DUF1391 family protein -
JJT18_RS10730 2237585..2237992 - 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
JJT18_RS10735 2238076..2238306 + 231 WP_000920568.1 dicB transcriptional regulator DicC -
JJT18_RS10740 2238290..2238568 + 279 Protein_2096 hypothetical protein -
JJT18_RS10745 2238603..2238752 + 150 WP_011443592.1 hypothetical protein -
JJT18_RS10750 2239189..2239521 - 333 WP_001301033.1 protein FlxA -
JJT18_RS10755 2239724..2240029 - 306 WP_001326990.1 hypothetical protein -
JJT18_RS10760 2240054..2240293 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
JJT18_RS10765 2240293..2240580 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
JJT18_RS10770 2240652..2240807 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
JJT18_RS10775 2241024..2241275 + 252 WP_000980994.1 hypothetical protein -
JJT18_RS10780 2241342..2241620 + 279 WP_012304870.1 hypothetical protein -
JJT18_RS10785 2241622..2242671 + 1050 WP_001265198.1 DUF968 domain-containing protein -
JJT18_RS10790 2242685..2243437 + 753 WP_001047135.1 antitermination protein -
JJT18_RS10795 2243715..2243804 - 90 WP_120795389.1 hypothetical protein -
JJT18_RS10800 2243859..2244071 - 213 WP_000087756.1 cold shock-like protein CspF -
JJT18_RS10805 2244372..2244587 + 216 WP_000066484.1 cold shock-like protein CspB -
JJT18_RS10810 2245341..2245556 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2221463..2254924 33461


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T186401 WP_000323025.1 NZ_CP067994:2240293-2240580 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T186401 NZ_CP089415:c2865916-2865665 [Xanthomonas oryzae pv. oryzae]
ATGCTACGGCTGCGTGAATTCCTGAGGCCGAAGAATCCCGATGCCGCGAGGCGGGCCGGCGAAGCGATTAGGCGCGGCGT
CCAGGCTCTCGGTGCCCACCCTCGAATGGGGCGGCTCATAGAAGATCTGTCTGAACAGTATCGGGAGTGGCTTATCGATT
TTGGGGATAGCGGCTATGTGGCTCGGTACCGCTTCGATGGGGATACCGTCACGATTTTGGCCGTGCGACACCAGAAGGAA
GCGGGGTACTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT186401 WP_000534858.1 NZ_CP067994:2240054-2240293 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT186401 NZ_CP089415:c2866221-2865943 [Xanthomonas oryzae pv. oryzae]
ATGGTTACGGCAACTTCCATCAAGCTTGATGATGAATTGAAAGGGCGGGTTCAGCACTTGGCAGAGTCGCGCCGGCGTAC
CCCGCATTGGATCATGCGCGAAGCCATTGAGCAGTACGTCGAGCGCGAGGAAAAGCGCGAGGCGCTGAACCGGGACACGC
TCAAGGCATGGGATGAATTTCAGGCGACTGGCCTGCATGTGACCGCTGAGGAAGTGGACAAGTGGCTCGCTAGCTGGGGA
ACTGACGACGAACTGCCTCCGCCAGAATGCCACAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References