266920

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 863356..863882 Replicon chromosome
Accession NZ_CP114892
Organism Escherichia coli strain CM5

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag O6Q95_RS04315 Protein ID WP_000323025.1
Coordinates 863356..863643 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag O6Q95_RS04320 Protein ID WP_000534858.1
Coordinates 863643..863882 (-) Length 80 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O6Q95_RS04265 (858380) 858380..858595 - 216 WP_000839590.1 phage lysis protein EssD -
O6Q95_RS04270 (858815) 858815..858985 + 171 WP_211180497.1 putative zinc-binding protein YnfU -
O6Q95_RS04275 (859349) 859349..859564 - 216 WP_000066484.1 cold shock-like protein CspB -
O6Q95_RS04280 (859865) 859865..860077 + 213 WP_000087756.1 cold shock-like protein CspF -
O6Q95_RS04285 (860132) 860132..860221 + 90 WP_120795389.1 hypothetical protein -
O6Q95_RS04290 (860499) 860499..861251 - 753 WP_001047135.1 antitermination protein -
O6Q95_RS04295 (861265) 861265..862314 - 1050 WP_001265198.1 DUF968 domain-containing protein -
O6Q95_RS04300 (862316) 862316..862594 - 279 WP_012304870.1 hypothetical protein -
O6Q95_RS04305 (862661) 862661..862912 - 252 WP_000980994.1 protein Rem -
O6Q95_RS04310 (863129) 863129..863284 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
O6Q95_RS04315 (863356) 863356..863643 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
O6Q95_RS04320 (863643) 863643..863882 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
O6Q95_RS04325 (863907) 863907..864212 + 306 WP_001326990.1 protein YdfV -
O6Q95_RS04330 (864415) 864415..864747 + 333 WP_001301033.1 FlxA-like family protein -
O6Q95_RS04335 (865184) 865184..865333 - 150 WP_011443592.1 protein YdfW -
O6Q95_RS04340 (865368) 865368..865646 - 279 Protein_855 protein YdfX -
O6Q95_RS04345 (865630) 865630..865860 - 231 WP_000920568.1 dicB transcriptional regulator DicC -
O6Q95_RS04350 (865944) 865944..866351 + 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
O6Q95_RS04355 (866518) 866518..866673 + 156 WP_000379575.1 DUF1391 family protein -
O6Q95_RS04360 (866675) 866675..866803 + 129 WP_000344964.1 protein YdfB -
O6Q95_RS04365 (866833) 866833..867051 + 219 WP_001171942.1 protein YdfC -
O6Q95_RS04370 (867619) 867619..867807 + 189 WP_000854559.1 cell division inhibition protein DicB -
O6Q95_RS04375 (867804) 867804..867995 + 192 WP_001083297.1 lysis protein YdfD -
O6Q95_RS04380 (868088) 868088..868855 + 768 Protein_863 exonuclease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 849012..883809 34797


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T266920 WP_000323025.1 NZ_CP114892:c863643-863356 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp


Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT266920 WP_000534858.1 NZ_CP114892:c863882-863643 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9


Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References