Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1629615..1630141 Replicon chromosome
Accession NZ_LR881938
Organism Escherichia coli str. K-12 substr. MG1655 strain K-12

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag IEU92_RS07965 Protein ID WP_000323025.1
Coordinates 1629615..1629902 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag IEU92_RS07970 Protein ID WP_000534858.1
Coordinates 1629902..1630141 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IEU92_RS07920 1624639..1624854 - 216 WP_000839590.1 phage lysis protein EssD -
IEU92_RS07925 1625608..1625823 - 216 WP_000066484.1 cold shock-like protein CspB -
IEU92_RS07930 1626124..1626336 + 213 WP_000087756.1 cold shock-like protein CspF -
IEU92_RS07935 1626391..1626480 + 90 WP_120795389.1 hypothetical protein -
IEU92_RS07940 1626758..1627510 - 753 WP_001047135.1 antitermination protein -
IEU92_RS07945 1627524..1628573 - 1050 WP_001393597.1 DUF968 domain-containing protein -
IEU92_RS07950 1628575..1628853 - 279 WP_012304870.1 hypothetical protein -
IEU92_RS07955 1628920..1629171 - 252 WP_000980994.1 hypothetical protein -
IEU92_RS07960 1629388..1629543 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
IEU92_RS07965 1629615..1629902 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
IEU92_RS07970 1629902..1630141 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
IEU92_RS07975 1630166..1630471 + 306 WP_001326990.1 hypothetical protein -
IEU92_RS07980 1630674..1631006 + 333 WP_001301033.1 protein FlxA -
IEU92_RS07985 1631443..1631592 - 150 WP_011443592.1 hypothetical protein -
IEU92_RS07990 1631627..1631905 - 279 Protein_1560 hypothetical protein -
IEU92_RS07995 1631889..1632119 - 231 WP_000920568.1 dicB transcriptional regulator DicC -
IEU92_RS08000 1632203..1632610 + 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
IEU92_RS08005 1632777..1632932 + 156 WP_000379575.1 DUF1391 family protein -
IEU92_RS08010 1633092..1633310 + 219 WP_001171942.1 hypothetical protein -
IEU92_RS08015 1633878..1634066 + 189 WP_000854559.1 cell division inhibition protein DicB -
IEU92_RS08020 1634063..1634254 + 192 WP_001083297.1 lysis protein YdfD -
IEU92_RS08025 1634347..1635114 + 768 Protein_1567 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1615271..1648732 33461


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T289514 WP_000323025.1 NZ_LR881938:c1629902-1629615 [Escherichia coli str. K-12 substr. MG1655]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT289514 WP_000534858.1 NZ_LR881938:c1630141-1629902 [Escherichia coli str. K-12 substr. MG1655]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References