289514

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1629615..1630141 Replicon chromosome
Accession NZ_LR881938
Organism Escherichia coli str. K-12 substr. MG1655 strain K-12

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag IEU92_RS07965 Protein ID WP_000323025.1
Coordinates 1629615..1629902 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag IEU92_RS07970 Protein ID WP_000534858.1
Coordinates 1629902..1630141 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IEU92_RS07920 1624639..1624854 - 216 WP_000839590.1 phage lysis protein EssD -
IEU92_RS07925 1625608..1625823 - 216 WP_000066484.1 cold shock-like protein CspB -
IEU92_RS07930 1626124..1626336 + 213 WP_000087756.1 cold shock-like protein CspF -
IEU92_RS07935 1626391..1626480 + 90 WP_120795389.1 hypothetical protein -
IEU92_RS07940 1626758..1627510 - 753 WP_001047135.1 antitermination protein -
IEU92_RS07945 1627524..1628573 - 1050 WP_001393597.1 DUF968 domain-containing protein -
IEU92_RS07950 1628575..1628853 - 279 WP_012304870.1 hypothetical protein -
IEU92_RS07955 1628920..1629171 - 252 WP_000980994.1 hypothetical protein -
IEU92_RS07960 1629388..1629543 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
IEU92_RS07965 1629615..1629902 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
IEU92_RS07970 1629902..1630141 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
IEU92_RS07975 1630166..1630471 + 306 WP_001326990.1 hypothetical protein -
IEU92_RS07980 1630674..1631006 + 333 WP_001301033.1 protein FlxA -
IEU92_RS07985 1631443..1631592 - 150 WP_011443592.1 hypothetical protein -
IEU92_RS07990 1631627..1631905 - 279 Protein_1560 hypothetical protein -
IEU92_RS07995 1631889..1632119 - 231 WP_000920568.1 dicB transcriptional regulator DicC -
IEU92_RS08000 1632203..1632610 + 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
IEU92_RS08005 1632777..1632932 + 156 WP_000379575.1 DUF1391 family protein -
IEU92_RS08010 1633092..1633310 + 219 WP_001171942.1 hypothetical protein -
IEU92_RS08015 1633878..1634066 + 189 WP_000854559.1 cell division inhibition protein DicB -
IEU92_RS08020 1634063..1634254 + 192 WP_001083297.1 lysis protein YdfD -
IEU92_RS08025 1634347..1635114 + 768 Protein_1567 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1615271..1648732 33461


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T289514 WP_000323025.1 NZ_LR881938:c1629902-1629615 [Escherichia coli str. K-12 substr. MG1655]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT289514 WP_000534858.1 NZ_LR881938:c1630141-1629902 [Escherichia coli str. K-12 substr. MG1655]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References