276667

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1235428..1235954 Replicon chromosome
Accession NZ_CP122316
Organism Escherichia coli strain HT-946

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag QCG48_RS06065 Protein ID WP_000323025.1
Coordinates 1235667..1235954 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag QCG48_RS06060 Protein ID WP_000534858.1
Coordinates 1235428..1235667 (+) Length 80 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCG48_RS06000 (1230455) 1230455..1231222 - 768 Protein_1169 exonuclease -
QCG48_RS06005 (1231315) 1231315..1231506 - 192 WP_001083297.1 lysis protein YdfD -
QCG48_RS06010 (1231503) 1231503..1231691 - 189 WP_000854559.1 cell division inhibition protein DicB -
QCG48_RS06015 (1232259) 1232259..1232477 - 219 WP_001171942.1 protein YdfC -
QCG48_RS06020 (1232507) 1232507..1232635 - 129 WP_000344964.1 protein YdfB -
QCG48_RS06025 (1232637) 1232637..1232792 - 156 WP_000379575.1 DUF1391 family protein -
QCG48_RS06030 (1232959) 1232959..1233366 - 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
QCG48_RS06035 (1233450) 1233450..1233680 + 231 WP_000920568.1 dicB transcriptional regulator DicC -
QCG48_RS06040 (1233664) 1233664..1233942 + 279 Protein_1177 protein YdfX -
QCG48_RS06045 (1233977) 1233977..1234126 + 150 WP_011443592.1 protein YdfW -
QCG48_RS06050 (1234563) 1234563..1234895 - 333 WP_001301033.1 FlxA-like family protein -
QCG48_RS06055 (1235098) 1235098..1235403 - 306 WP_001326990.1 protein YdfV -
QCG48_RS06060 (1235428) 1235428..1235667 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
QCG48_RS06065 (1235667) 1235667..1235954 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
QCG48_RS06070 (1236026) 1236026..1236181 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
QCG48_RS06075 (1236398) 1236398..1236649 + 252 WP_000980994.1 protein Rem -
QCG48_RS06080 (1236716) 1236716..1236994 + 279 WP_012304870.1 hypothetical protein -
QCG48_RS06085 (1236996) 1236996..1238045 + 1050 WP_001393597.1 DUF968 domain-containing protein -
QCG48_RS06090 (1238059) 1238059..1238811 + 753 WP_001047135.1 antitermination protein -
QCG48_RS06095 (1239089) 1239089..1239178 - 90 WP_120795389.1 hypothetical protein -
QCG48_RS06100 (1239233) 1239233..1239445 - 213 WP_000087756.1 cold shock-like protein CspF -
QCG48_RS06105 (1239746) 1239746..1239961 + 216 WP_000066484.1 cold shock-like protein CspB -
QCG48_RS06110 (1240325) 1240325..1240495 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
QCG48_RS06115 (1240715) 1240715..1240930 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1216837..1250298 33461


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T276667 WP_000323025.1 NZ_CP122316:1235667-1235954 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp


Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT276667 WP_000534858.1 NZ_CP122316:1235428-1235667 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9


Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References