262693

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1732987..1733513 Replicon chromosome
Accession NZ_CP110016
Organism Escherichia coli strain HE_100

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag OLR74_RS08625 Protein ID WP_000323025.1
Coordinates 1732987..1733274 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag OLR74_RS08630 Protein ID WP_000534858.1
Coordinates 1733274..1733513 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLR74_RS08575 (1728011) 1728011..1728226 - 216 WP_000839590.1 phage lysis protein EssD -
OLR74_RS08580 (1728446) 1728446..1728616 + 171 WP_211180497.1 putative zinc-binding protein YnfU -
OLR74_RS08585 (1728980) 1728980..1729195 - 216 WP_000066484.1 cold shock-like protein CspB -
OLR74_RS08590 (1729496) 1729496..1729708 + 213 WP_000087756.1 cold shock-like protein CspF -
OLR74_RS08595 (1729763) 1729763..1729852 + 90 WP_120795389.1 hypothetical protein -
OLR74_RS08600 (1730130) 1730130..1730882 - 753 WP_001047135.1 antitermination protein -
OLR74_RS08605 (1730896) 1730896..1731945 - 1050 WP_001265198.1 DUF968 domain-containing protein -
OLR74_RS08610 (1731947) 1731947..1732225 - 279 WP_012304870.1 hypothetical protein -
OLR74_RS08615 (1732292) 1732292..1732543 - 252 WP_000980994.1 protein Rem -
OLR74_RS08620 (1732760) 1732760..1732915 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
OLR74_RS08625 (1732987) 1732987..1733274 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
OLR74_RS08630 (1733274) 1733274..1733513 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
OLR74_RS08635 (1733538) 1733538..1733843 + 306 WP_001326990.1 protein YdfV -
OLR74_RS08640 (1734046) 1734046..1734378 + 333 WP_001301033.1 FlxA-like family protein -
OLR74_RS08645 (1734815) 1734815..1734964 - 150 WP_011443592.1 protein YdfW -
OLR74_RS08650 (1734999) 1734999..1735277 - 279 Protein_1692 protein YdfX -
OLR74_RS08655 (1735261) 1735261..1735491 - 231 WP_000920568.1 dicB transcriptional regulator DicC -
OLR74_RS08660 (1735575) 1735575..1735982 + 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
OLR74_RS08665 (1736149) 1736149..1736304 + 156 WP_000379575.1 DUF1391 family protein -
OLR74_RS08670 (1736306) 1736306..1736434 + 129 WP_000344964.1 protein YdfB -
OLR74_RS08675 (1736464) 1736464..1736682 + 219 WP_001171942.1 protein YdfC -
OLR74_RS08680 (1737250) 1737250..1737438 + 189 WP_000854559.1 cell division inhibition protein DicB -
OLR74_RS08685 (1737435) 1737435..1737626 + 192 WP_001083297.1 lysis protein YdfD -
OLR74_RS08690 (1737719) 1737719..1738486 + 768 Protein_1700 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1718643..1753440 34797


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T262693 WP_000323025.1 NZ_CP110016:c1733274-1732987 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT262693 WP_000534858.1 NZ_CP110016:c1733513-1733274 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References