126454

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1769860..1770386 Replicon chromosome
Accession NZ_CP040667
Organism Escherichia coli strain S17-1

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag FGH86_RS08555 Protein ID WP_000323025.1
Coordinates 1770099..1770386 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag FGH86_RS08550 Protein ID WP_000534858.1
Coordinates 1769860..1770099 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGH86_RS08490 1764887..1765654 - 768 Protein_1651 exonuclease -
FGH86_RS08495 1765747..1765938 - 192 WP_001083297.1 lysis protein YdfD -
FGH86_RS08500 1765935..1766123 - 189 WP_000854559.1 cell division inhibition protein DicB -
FGH86_RS08510 1766691..1766909 - 219 WP_001171942.1 hypothetical protein -
FGH86_RS08515 1767069..1767224 - 156 WP_000379575.1 DUF1391 family protein -
FGH86_RS08520 1767391..1767798 - 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
FGH86_RS08525 1767882..1768112 + 231 WP_000920568.1 dicB transcriptional regulator DicC -
FGH86_RS08530 1768096..1768374 + 279 Protein_1658 hypothetical protein -
FGH86_RS08535 1768409..1768558 + 150 WP_011443592.1 hypothetical protein -
FGH86_RS08540 1768995..1769327 - 333 WP_001301033.1 protein FlxA -
FGH86_RS08545 1769530..1769835 - 306 WP_001326990.1 hypothetical protein -
FGH86_RS08550 1769860..1770099 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
FGH86_RS08555 1770099..1770386 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
FGH86_RS08560 1770458..1770613 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
FGH86_RS08565 1770830..1771081 + 252 WP_000980994.1 hypothetical protein -
FGH86_RS08570 1771148..1771426 + 279 WP_012304870.1 hypothetical protein -
FGH86_RS08575 1771428..1772477 + 1050 WP_001265198.1 DUF968 domain-containing protein -
FGH86_RS08580 1772491..1773243 + 753 WP_001047135.1 antitermination protein -
FGH86_RS08585 1773521..1773610 - 90 WP_120795389.1 hypothetical protein -
FGH86_RS08590 1773665..1773877 - 213 WP_000087756.1 cold shock-like protein CspF -
FGH86_RS08595 1774178..1774393 + 216 WP_000066484.1 cold shock-like protein CspB -
FGH86_RS08600 1775147..1775362 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1751269..1784730 33461


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T126454 WP_000323025.1 NZ_CP040667:1770099-1770386 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T126454 NZ_CP040667:1770099-1770386 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT126454 WP_000534858.1 NZ_CP040667:1769860-1770099 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT126454 NZ_CP040667:1769860-1770099 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References