Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1769860..1770386 Replicon chromosome
Accession NZ_CP040667
Organism Escherichia coli strain S17-1

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag FGH86_RS08555 Protein ID WP_000323025.1
Coordinates 1770099..1770386 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag FGH86_RS08550 Protein ID WP_000534858.1
Coordinates 1769860..1770099 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGH86_RS08490 1764887..1765654 - 768 Protein_1651 exonuclease -
FGH86_RS08495 1765747..1765938 - 192 WP_001083297.1 lysis protein YdfD -
FGH86_RS08500 1765935..1766123 - 189 WP_000854559.1 cell division inhibition protein DicB -
FGH86_RS08510 1766691..1766909 - 219 WP_001171942.1 hypothetical protein -
FGH86_RS08515 1767069..1767224 - 156 WP_000379575.1 DUF1391 family protein -
FGH86_RS08520 1767391..1767798 - 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
FGH86_RS08525 1767882..1768112 + 231 WP_000920568.1 dicB transcriptional regulator DicC -
FGH86_RS08530 1768096..1768374 + 279 Protein_1658 hypothetical protein -
FGH86_RS08535 1768409..1768558 + 150 WP_011443592.1 hypothetical protein -
FGH86_RS08540 1768995..1769327 - 333 WP_001301033.1 protein FlxA -
FGH86_RS08545 1769530..1769835 - 306 WP_001326990.1 hypothetical protein -
FGH86_RS08550 1769860..1770099 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
FGH86_RS08555 1770099..1770386 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
FGH86_RS08560 1770458..1770613 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
FGH86_RS08565 1770830..1771081 + 252 WP_000980994.1 hypothetical protein -
FGH86_RS08570 1771148..1771426 + 279 WP_012304870.1 hypothetical protein -
FGH86_RS08575 1771428..1772477 + 1050 WP_001265198.1 DUF968 domain-containing protein -
FGH86_RS08580 1772491..1773243 + 753 WP_001047135.1 antitermination protein -
FGH86_RS08585 1773521..1773610 - 90 WP_120795389.1 hypothetical protein -
FGH86_RS08590 1773665..1773877 - 213 WP_000087756.1 cold shock-like protein CspF -
FGH86_RS08595 1774178..1774393 + 216 WP_000066484.1 cold shock-like protein CspB -
FGH86_RS08600 1775147..1775362 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1751269..1784730 33461


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T126454 WP_000323025.1 NZ_CP040667:1770099-1770386 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T126454 NZ_CP040667:1770099-1770386 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT126454 WP_000534858.1 NZ_CP040667:1769860-1770099 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT126454 NZ_CP040667:1769860-1770099 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References